Post Hoc Sub-analysis
Post hoc sub-analysis was performed by stratifying patients by their
preoperative peak troponin level using a clinically meaningful threshold
of troponin >10.00 ng/mL to define the high-risk and ≤10.00
ng/mL for the low-risk cohorts. This resulted in 957 (79.0%) low-risk
and 254 (21.0%) high-risk patients. In this analysis, there were no
differences in intensive care unit or hospital length of stay
(Supplemental Table 3 ). Additionally, both 30-day, 90-day,
one-, and five-year survival were similar (Figure 3 ). Cox
proportional hazards modeling did not find peak troponin above 10.00
ng/mL to be a significant predictor of five-year mortality in
univariable (HR 1.11, 95% CI 0.80 to 1.55, P=0.543) or multivariable
(HR 0.94, 95% CI 0.66 to 1.33, P=0.713) analysis (Supplemental
Table 4 ). Furthermore, peak troponin >10.00 ng/mL was also
not found to be a significant predictor of 5-year MACCE in univariable
(HR 0.90, 95% CI 0.70 to 1.17, P=0.427) or multivariable (HR 0.80, 95%
CI 0.61 to 1.05, P=0.110) models (Supplemental Table 5 ).