Period 2008 - 2013
The extent of disease was assessed by the Chang classification. Maximum
safe surgical resection was attempted. Post-operative brain and spine
MRIs were obtained within a month after surgery. CSF analyses were
performed prior to initial treatment. Patients were classified as high
risk based on the presence anaplastic subtype, evidence of metastasis,
and/or residual tumor >1.5cm2. All patients received CSI at
a dose of 36Gy with an additional boost to the posterior fossa of
18-24Gy for a total dose of 54-60Gy given in fractions of 1.8Gy five
times per week.
Patients received weekly 1.5mg/m2 vincristine concomitantly with
radiation. Patients then received maintenance chemotherapy consisting of
eight cycles of vincristine, cisplatin, and cyclophosphamide.
Vincristine was given on days 1, 8, 15 at a dose of 1.5mg/m2. Cisplatin
was given on day 1 at a dose of 75mg/m2. Finally, cyclophosphamide was
given on days 22 and 23 at a dose of 1000mg/m2 17.