Statistical analysis
All data were summarized using standard descriptive statistics.
Event-free (EFS) and overall survival (OS) estimates were obtained using
the Kaplan-Meier method and presented with corresponding 95% confidence
intervals. EFS was defined as the time elapsed from diagnosis to the
date of first progression, death, or censoring. OS was defined as the
time elapsed from diagnosis to death or censoring. Cox proportional
hazard models were used to assess the effect of demographic and clinical
variables on survival. Model estimates were presented as hazard ratios
and corresponding 95% confidence intervals. All p-values were two-sided
and those <0.05 were considered statistically significant.
Statistical analyses were performed using R statistical software (R
Foundation for Statistical Computing, Vienna, Austria) with the survival
and survminer packages.