Data Collection
A total of 16 gene expression datasets including 15 publicly available
expression datasets were meta-analyzed in this study. Transcriptomes of
SARS-coV-2 infected lung tissues matched with healthy control and
SARS-coV-2 treated A549 cells were obtained from GEO (Accession ID
GSE147507). Transcriptome data of bronchoalveolar lavage fluid (BALF)
and peripheral blood mononuclear cells (PBMC) were obtained from the
recently published study . Differentially expressed genes (DEG) from the
expression profiles of systemic lupus erythematosus (Accession ID:
GSE112087), bone marrow cells treated with lenalidomide (Accession ID:
GSE106748), lymphoma cells treated with lenalidomide (Accession ID:
GSE60618), CD34 positive cells treated with pomalidomide (Accession ID:
GSE144052), MERS infected PBMC (Accession: GSE1739), lenalidomide
treated PBMC (Accession ID: GSE84251) and CC-122 treated lymphoma cells
(Accession ID: GSE75420) were obtained using limma from the GEO
database. Library of Integrated Network-Based Cellular Signatures
(iLINCS) is a database which contains the gene expression signatures of
more than 21,000 compounds (http://www.ilincs.org/ilincs/). We
obtained the gene expression signatures for A549 cells treated with 10µM
thalidomide for 6h (LINCSCP_4683) and 24h (LINCSCP_4463), 100 µM
lenalidomide for 6h (LINCSCP_4650) and 24h (LINCSCP_4427).