An increased fluorescence signal was also detected in the lung area, indicating successful imaging of PE in a murine model (Figure 15) (Lim et al., 2017). In another in vivo study of PE, these activated GPIIb/IIIa targeted MPIOs demonstrated focal accumulation within the edematous area in the lung via T2 MRI (Figure 16) (Heidt et al., 2016). Using the same particles, von Elverfeldt et al. successfully imaged platelet-driven inflammation in the myocardium of an I/R injury mouse model (von Elverfeldt et al., 2014). This activated-platelet targeted MPIOS compared favourably to a standard gadolinium imaging of myocardial necrosis (Figure 17) (von Elverfeldt et al., 2014).