Statistical analysis
SPSS 25.0 statistical package (IBM Corp, Armonk, NK, USA ) was used. Saphiro-Wilk test was used to test normality. Continuous variables were presented with mean ± standard deviation (SD) or median and interquartile range (IQR). Categorical variables were presented in absolute and relative frequency. Two-side unpaired t-test andFischer´s-exact test were used for comparison of continuous and categorical variables, respectively. Kaplan-Meier analysis was used for survival analysis.