Statistical analysis
SPSS 25.0 statistical package (IBM Corp, Armonk, NK, USA ) was
used. Saphiro-Wilk test was used to test normality. Continuous
variables were presented with mean ± standard deviation (SD) or median
and interquartile range (IQR). Categorical variables were presented in
absolute and relative frequency. Two-side unpaired t-test andFischer´s-exact test were used for comparison of continuous and
categorical variables, respectively. Kaplan-Meier analysis was
used for survival analysis.