Author contribution statement
ES, EC, and GMe carried out the experiments and data collection. ES; AA; EE; IB; FC; EC; FB; GD; AD; LF; FLR; LML; DM; GMa; GMe; MM; EN; RO; EAP; SP; AR; FR; AR; MG; LC, VP; DV and RA recruited the patients. ES performed the statistical analysis. ES and RA conceived the study and assisted in data interpretation. All authors reviewed, edited and approved the final manuscript.