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\begin{document}

\title{Echocardiographic reference ranges for normal cardiac Doppler data in
healthy Turkish population : ECHO-DOP-TR Trial}



\author[1]{Özgen Şafak}%
\author[2]{Mustafa Gürsoy}%
\author[2]{Sadik Emren}%
\author[3]{Emre Demir}%
\author[1]{Tarik Yildirim}%
\author[1]{Onur Argan}%
\author[4]{Ersin Simsek}%
\author[5]{Fatih Aytemiz}%
\author[2]{Emre Özdemir}%
\author[6]{Nermin Bayar}%
\author[7]{Zehra Erkal}%
\author[8]{Oguzhan Celik}%
\author[9]{Onur Akhan}%
\author[10]{Cevdet  Dönmez}%
\author[11]{Tugba Kemaloglu Oz}%
\author[12]{Serdar Akyel}%
\author[13]{Oktay Ergene}%
\author[14]{Mehmet Ozkan}%
\affil[1]{Balikesir University Faculty of Medicine}%
\affil[2]{Izmir Katip Celebi University Faculty of Medicine}%
\affil[3]{Ege University Faculty of Medicine}%
\affil[4]{Balıkesir State Hospital}%
\affil[5]{Manisa State Hospital}%
\affil[6]{Antalya Education and Research Hospital}%
\affil[7]{Antalya Training and Research Hospital}%
\affil[8]{Hitit University Faculty of Medicine}%
\affil[9]{Bilecik State Hospital}%
\affil[10]{Dr Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital}%
\affil[11]{Liv Hospital}%
\affil[12]{Kastamonu University Faculty of Medicine}%
\affil[13]{Dokuz Eylül University}%
\affil[14]{Kosuyolu  Kartal Heart Education and Research Hospital}%


\vspace{-1em}



  
  \date{June 15, 2024}


\begingroup
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\selectlanguage{english}
\begin{abstract}
Aim Doppler echocardiography has become the standard imaging modality
for diastolic function and provide pathophysiological insight into
systolic and diastolic heart failure. In this study we aimed to obtain
normal echocardiographic Doppler parameters of healthy Turkish
population. Methods Among 31 collaborating institutions from all regions
of Turkey, 1154 healthy volunteers were enrolled in this study.
Predefined protocols were used for all participants during
echocardiographic examination and The American Society of
Echocardiography and European Association of Cardiovascular Imaging
recommendations were used for echocardiographic Doppler measurements.
Results A total of 967 healthy participants were enrolled in this study
after applying exclusion criteria. Echocardiographic examination was
obtained from all subjects following predefined protocols. Mitral E wave
velocity and E/A ratio were higher in females and decreased
progressively in advancing ages. E wave deceleration time and A wave
velocity were increased with aging. Assessment of tissue Doppler
velocities showed that left ventricular lateral e', septal e' and septal
s' were higher in younger subjects and in females. E/e' ratio was
increased progressively with advancing decades. Right ventricular e'and
s' were decreased but a' was increased with increasing age. Septal e'
lower than 8 cm/s was 1.9\% in the fifth decade and 13.7\% in ages older
than 50-years. The E/e' ratio greater than 15 (and also 13) was not
found. Conclusion This study, for the first time, provides
echocardiographic reference ranges for normal cardiac Doppler data in
healthy Turkish population which will be useful in routine clinical
practice as well as in future clinical trials.%
\end{abstract}%



\sloppy


\textbf{Echocardiographic reference ranges for normal cardiac Doppler
data in healthy Turkish population : ECHO-DOP-TR Trial}

\textbf{Aim}

Doppler echocardiography has become the standard imaging modality for
diastolic function and provide pathophysiological insight into systolic
and diastolic heart failure. In this study we aimed to obtain normal
echocardiographic Doppler parameters of healthy Turkish population.

\textbf{Methods}

Among 31 collaborating institutions from all regions of Turkey, 1154
healthy volunteers were enrolled in this study. Predefined protocols
were used for all participants during echocardiographic examination and
The American Society of Echocardiography and European Association of
Cardiovascular Imaging recommendations were used for echocardiographic
Doppler measurements.

\textbf{Results}

A total of 967 healthy participants were enrolled in this study after
applying exclusion criteria. Echocardiographic examination was obtained
from all subjects following predefined protocols. Mitral E wave velocity
and E/A ratio were higher in females and decreased progressively in
advancing ages. E wave deceleration time and A wave velocity were
increased with aging. Assessment of tissue Doppler velocities showed
that left ventricular lateral e', septal e' and septal s' were higher in
younger subjects and in females. E/e' ratio was increased progressively
with advancing decades. Right ventricular e'and s' were decreased but a'
was increased with increasing age. Septal e' lower than 8 cm/s was 1.9\%
in the fifth decade and 13.7\% in ages older than 50-years. The E/e'
ratio greater than 15 (and also 13) was not found.

\textbf{Conclusion}

This study, for the first time, provides echocardiographic reference
ranges for normal cardiac Doppler data in healthy Turkish population
which will be useful in routine clinical practice as well as in future
clinical trials.

\textbf{Introduction}

Echocardiography is widely used as a noninvasive cardiac imaging
technique in the clinical setting for the evaluation of heart structure
and functions. Doppler echocardiography is a method used to identify the
direction and velocity of blood flow and therefore, it is an integral
part of the cardiovascular echocardiographic examination, providing a
precise hemodyanamic evaluation of the heart (1).

Blood and tissue velocities measured by Doppler are widely used tools
for the evaluation of cardiac systolic and diastolic functions. Blood
flow causes high frequency, low amplitude signals that are obtained
using Pulse Wave (PW) Doppler. Tissue Doppler Imaging (TDI) is designed
to characterise low velocity, high amplitude signals from myocardial
motion, and are obtained by inverting the low pass filter used in
traditional Doppler to a high pass filter (2,3). Tissue Doppler imaging
examines the longitudinal component of myocardial contraction throughout
the cardiac cycle.

The diastolic parameters may show difference in distinct patient
subgroups. Age-related changes in diastolic indices have also been found
to be gender specific. In the elderly population, diastolic function
deteriorates more significantly in female gender than in male.
Furthermore, although standart Doppler values have been established in
current guidelines, these values may also be variable according to
racial and ethnical factors. Therefore, it is important to be aware of
the normal reference values of cardiac Doppler data in the clinical
setting according to age, gender, race and body surface area (4).

Recently, we, for the first time in Turkey, have reported
two-dimensional echocardiographic normal reference ranges for cardiac
chamber quantification in a large cohort of Turkish individuals (5).
Besides the chamber sizes, essential data regarding the relationship
between these measurements and age, gender, body surface area and
geographical region-dependent differences have been provided.

In this study, we aimed to determine echocardiographic reference values
for PW Doppler and TDI velocities in a healthy Turkish population to
obtain normal Doppler findings and patterns according to age and gender.

\textbf{Methods}

\emph{Study Population}

Between October 2016 and June 2019, 1046 healthy volunteers from all
regions of Turkey were evaluated in the study. The exclusion criteria
included the following; people under 18 years of age, patients who had
history of having any cardiovascular disease, hypertension, diabetes
mellitus, hyperlipidemia, systemic disease, glomerular filtration rate
under 60ml/min/1.73m\selectlanguage{ngerman}², genetical disease with cardiac involvement in the
first-degree relatives, electrocardiography (ECG) without sinus rhythm
or with left bundle branch block, waist circumference more than 102 cm
in men and 88 cm in women, high body mass index, abnormal glycaemia
values, smoking and/or alcohol abus\textbackslash{}soute, and regarding
the echocardiographical examination, any regurgitation of heart valves
more than mild, stenosis of any valve, left ventricular ejection
fraction less than 50\%, any wall motion abnormality, systolic pulmonary
artery pressure more than 35mmHg and volunteers with poor image quality.
Ultimately, 967 volunteers constituted the study population.

Baseline measurements included assessment of blood pressure, weight
(kilograms); height (centimeters), body mass index and body surface
area. Basic hematological and biochemical parameters were also recorded.

\emph{Echocardiographic examination}

ECG guided, standard two-dimensional transthoracic echocardiographic
studies were performed using available equipments VIVID 7 (General
Electric Company) and IE33 (Philips Company) instruments, with 1.5-4.0
MHz transducer, according to a predetermined protocol recommended by
American Society of Echocardiography and European Association of
Cardiovascular Imaging (EACVI) (3,6,7).

All studies were done with patients lying in the left lateral decubitus
position and breathing quietly. M-mode, 2D (frame rates .50--70 fps),
colour Doppler, PW Doppler, pulsed-wave tissue Doppler, and PW and TDI
(frame rates\selectlanguage{english}[?]110 s-1) data were obtained in all patients. PW Doppler was
obtained at the left and right ventricle outflow tract and continuous
wave Doppler at the aortic and pulmonary valve. Transmitral flow pattern
with E and A wave velocities was obtained with the sample volume
positioned at mitral leaflet tips. PW TDI was obtained at the septal and
lateral annular ring of the mitral valve, measuring s\selectlanguage{english}', e\selectlanguage{english}'and a\selectlanguage{english}' peak
velocities . PW TDI was also obtained at the lateral tricuspid annulus
in the four chamber view. Left atrium (LA) volume was measured from
standard apical 4-chamber views at end-systole just before mitral valve
opening. Left atrial volume index (LAVi) was calculated by dividing LA
volume by body surface area of subjects.

All Doppler echocardiographic images were recorded in a digital raw-data
format (native DICOM format), centralized and sent to core laboratory.
The images were evaluated by three experienced echocardiographers
blinded to any patient data.

\emph{Statistical analysis}

Statistical analysis was performed using IBM~SPSS Statistics for
Windows, Version 21.0. (IBM Corp. Armonk, NY: USA. Released 2012). The
normality distribution patterns of variables were evaluated using
histograms, probability plots, and analytical methods
(Kolmogorov-Smirnov). Variables showed as mean +- standard deviation.
Categorical variables were presented as percentages.~ Continuous data
was compared in gender and age groups using~independent T test and
One-way ANOVA respectively. Turkey's HSD was used in post-hoc
comparisons. Categorical variables~~ were compared using the Chi-square
test.~Pearson correlation test was performed for bivariate
correlations.~All tests were 2-tailed and the p value was less than 0.05
(p \textless{} 0.05) was accepted as significant.

Intra-observer and inter-observer variability was evaluated in 50
randomly selected subjects. Intraclass correlation coefficient with 95\%
confidence interval and the relative differences (means+-SD) were
reported overall. The Bland-Altman plot was drawn to obtain better
insights into the data quality between two echocardiographers.

\emph{Ethics committee}

The Healthy Heart ECHO-TR Trial respect the ethical principles for
conducting research on human subjects. The study protocol was approved
by 9 Eylul University Ethics Committee and written informed consent was
given by all subjects.

\textbf{Results}

\emph{Demographic data}

A total of 454 female (46.9\%) and 513 male (53.1\%) were included in
the study. The mean age of the study population (n= 967) was 33.6+-12.
The patients were grouped by age according to decades (4 groups). The
number of the healthy participants above 50 years of age was lower
compared to 3 other groups; therefore it was classified as a single
group.

The age of the study population was most commonly distributed between
18-29 (35.2\%) and 30-39 (32.4\%) years. With increasing decades, the
mean height of the volunteers was progressively decreased whereas
weight, body mass index (BMI), systolic and diastolic blood pressures,
serum creatinine levels, total cholesterol and low-density lipoprotein
(LDL) levels demonstrated a highly significant rise. Table 1 summarizes
the demographic data of each group.

\emph{Left ventricular parameters}

E and A wave velocities were higher in women than in men and E wave
tended to decrease with advancing age (p\textless{}0.05). E wave
deceleration time was increased in older ages and men had higher values
than women, showing a significant positive correlation with age and
gender (p\textless{}0.001 for both). The mean E/A ratios were 1.63+-0.49
(18-29 years), 1.43+-0.42 (30-39 years), 1.4+-0.4 (40-49 years), 1.25+-0.44
(\selectlanguage{english}[?]50 years) (with \textless{}0.001 p value for decades) (Figure-1).
Table-2 summarizes data regarding the PW Doppler velocities and LAVI
according to age and gender.

Septal e' and lateral e' waves were higher in the first decades and
women had higher levels than men, whereas septal a' and lateral a' waves
were higher in men and showed a negative correlation with advancing age
(all these parameters were statistically significant
(p\textless{}0.001). Septal s' and lateral s' waves tended to decrease
with advancing age, showing a negative correlation. Lateral and septal
s' waves were decreased progressively with advancing age. Lateral s'
wave was higher in men whereas septal s' wave was higher in women.

In four-chamber view, septal and lateral E/e' ratios were getting higher
with increasing age and women had a little bit higher value than men.
The average of septal and lateral E/e' ratio was 6.7+-1.3 (18-29 years),
7.6+-1.7 (30-39 years), 8.4+-2 (40-49 years), 8.9+-2.1 (\selectlanguage{english}[?]50 years)
(statistically not significant between decades) (Figure-2).

The intraclass correlation coefficient was obtained and the Bland-Altman
plot test was performed to gain better insights into the data quality
between two echocardiographers. In our study, the intraclass correlation
coefficient value was 0.965 (95\% CI: 0.975--0.992; p\textless{}0.001)
(Figure-3).

\emph{Right ventricular parameters}

Right ventricular s' and e' waves were decreased and a' wave tended to
increase with advancing age (13.1+-2.3, 12.7+-2.3, 12.4+-2.5, 12+-2.4 cm/s
for average s' waves, 14.5+-3.4, 13.9+-3.2, 13.2+-3.1, 11.7+-3.2 cm/s for
average e' waves, 11.6+-3, 12.6+-3.2, 13.7+-3.5, 14.9+-3.5 cm/s for average
a' waves with advancing ages). Besides, a' and e' waves were higher in
women than in men. Table-4 shows data about right ventricular TDI.

Discussion

This study provides normal reference ranges for cardiac Doppler
parameters of healthy Turkish population according to age and gender
using conventional recommended echocardiographic approaches including PW
Doppler and TDI.

E wave and also E/A ratio were slightly higher in women than in men, and
tended to decrease with advancing ages, which were statistically
significant. On the other hand A wave and E wave deceleration time (Edt)
were increased with advancing decades. These results were similar to
data reported in European and American echocardiographic studies
(2,3,6,7).

Most diastolic parameters varied and changed according to age similarly
for both genders. Lateral and septal e' were lower in men and in older
population, whereas lateral a' and septal a' had a positive correlation
with age and were slightly higher in men. These parameters were found to
be prominently higher in a study authored by Nagueh et al. (8) when
compared with our study . For example, the septal e' wave velocities
they obtained were 14.9+-2.4 cm/s (16-20 years), 15.5+-2.7 cm/s (21-40
years), 12.2+-2.3 cm/s (41-60 years) and 10.4+-2.1 cm/s (\selectlanguage{english}[?]61 years)
according to ages. On the other hand, Chahal et al. (9) obtained similar
results when compared with our study and, reported the septal e'wave
8.6+-1.9 cm/s as an average value.

For evaluation of the left ventricular diastolic function, e', E/A and
E/e' values are highly important and are known to have a positive
correlation with left ventricular filling pressures. In our study we did
not observe any value of septal (and also lateral) e' lower than 8 cm/s
whereas in the study authored by Cabellero et al. (10) 2 out of 170
(1.2\%) in 20-40 years, 38 out of 193 (19.7\%) in 40-60 years, 46 out of
83 (55.4\%) in \selectlanguage{english}[?]60 years had values lower than 8 cm/s. Indeed, LAVI of
participants were lower than 34 mL/m2 in all age groups. E/A ratio was
decreased with increasing age, as shown in several previous studies
(10-13). E/e' tended to increase in older ages but none of the
participants had a value higher than 15, although it has been reported
in some European studies (11). In the present study, E/e' was found to
be slightly higher in women compared to men, although it was not
statistically significant. Several studies have previously showed that
there is relatively a higher incidence of deteriorated diastolic
functions in elderly female patients and higher cardiovascular mortality
in female gender when compared to men (14-16).

s' wave velocity measures longitudinal LV contraction and is a surrogate
of LV systolic function and it is also well-known that it has a good
correlation with left ventricular ejection fraction (LVEF). s' wave
velocity \selectlanguage{english}[?]7.5 cm/s has a sensitivity of 79\% and a specificity of 88\%
in predicting LVEF \selectlanguage{english}[?]50\% (2, 17). As summarized in Table-3, lateral s'
was higher than septal s' in our study and also higher in younger
volunteers. Lateral s' was higher in men whereas septal s' was higher in
women, concordant with previous data (12,13).

Meluzin and co-workers (17), reported good correlation between right
ventricular (RV) s' wave velocity and right ventricular ejection
fraction (RVEF); RV s' wave velocity \textless{}11.5 cm/s predicted RV
dysfunction (EF \textless{} 45\%) with a sensitivity of 90\% and
specificity of 85\%. In our study, none of the participants had a lower
RVs wave than these established data. Ischemic heart diseases, chronic
pulmonary hypertension and chronic lung diseases can cause a decrease in
RV s' wave velocity which should be evaluated during echocardiographical
examinations.

In the present study, right ventricular parameters also exhibited
gender-related differences, e' and a' were higher in women whereas s'
wave was higher in men. s' and e' wave velocities were decreased with
advancing ages as demonstrated in previous studies (10,11, 13).

Systolic pulmonary artery pressure (sPAP), an important predictor of
several cardiac abnormalities, was also evaluated in the current study.
We did not obtain any sPAP above 36 mmHg in healthy volunteers, whereas,
higher levels have been rarely detected in past studies (11). However,
it should be kept in mind that echocardiography is a observer-dependent
modality, and the patients with slightly elevated pulmonary artery
pressure should be evaluated with further imaging modality to avoid
under-diagnosis of any organic heart disease.

In conclusion, the current data obtained from healthy Turkish volunteers
are comparable with most previous studies in this era
(2,3,5,6,10,11,13,18). E and A waves of mitral annulus and also E/A
ratios were greater compared to European registries, but these
differences were not statisitically significant. Data regarding E/e'
ratio especially seems interesting, as in a European study (6) that it
has been found to be significantly increased in advancing ages whereas
no remarkable difference has been detected in our study. But we have to
emphasize that E/e' higher than 15 is correlated with diastolic
dysfunction and the study above-mentioned had several participants with
these values (0.05\% of the population) (11).

As being the first large-scaled healthy population based Doppler study
in Turkey, ECHO-DOP-TR provides essential data regarding left and right
ventricular PW Doppler and TDI studies, and helps us to evaluate the
systolic and diastolic functions of the heart.

Limitations

The results mainly pertain to Turkish population who live in Turkey, a
bridge country between Europe and Asia. Despite the fact that all
patients were considered healthy normal subjects, the possibility of
subclinical coronary artery disease particularly in older subjects
cannot be excluded. The study groups were not equally distributed
according to age as it was not easy to find healthy patient without any
chronic disease in advancing ages. The data regarding e' and a' waves in
inferior, anterior, posterior segments are unavailable in most of the
patients and therefore were not included in the Results section.

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\end{enumerate}\selectlanguage{english}
\begin{longtable}[]{@{}lllllllll@{}}
\toprule
\begin{minipage}[b]{0.08\columnwidth}\raggedright\strut
Table-1 Demographic data of the population\strut
\end{minipage} & \begin{minipage}[b]{0.08\columnwidth}\raggedright\strut
Table-1 Demographic data of the population\strut
\end{minipage} & \begin{minipage}[b]{0.08\columnwidth}\raggedright\strut
Table-1 Demographic data of the population\strut
\end{minipage} & \begin{minipage}[b]{0.08\columnwidth}\raggedright\strut
Table-1 Demographic data of the population\strut
\end{minipage} & \begin{minipage}[b]{0.08\columnwidth}\raggedright\strut
Table-1 Demographic data of the population\strut
\end{minipage} & \begin{minipage}[b]{0.08\columnwidth}\raggedright\strut
Table-1 Demographic data of the population\strut
\end{minipage} & \begin{minipage}[b]{0.08\columnwidth}\raggedright\strut
Table-1 Demographic data of the population\strut
\end{minipage} & \begin{minipage}[b]{0.08\columnwidth}\raggedright\strut
Table-1 Demographic data of the population\strut
\end{minipage} & \begin{minipage}[b]{0.08\columnwidth}\raggedright\strut
Table-1 Demographic data of the population\strut
\end{minipage}\tabularnewline
\midrule
\endhead
\begin{minipage}[t]{0.11\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.11\columnwidth}\raggedright\strut
18-29 years (n:341) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.11\columnwidth}\raggedright\strut
30-39 years (n:314) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.11\columnwidth}\raggedright\strut
40-49 years (n:202) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.11\columnwidth}\raggedright\strut
[?]50 years (n:110) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.11\columnwidth}\raggedright\strut
p*\strut
\end{minipage} & \begin{minipage}[t]{0.11\columnwidth}\raggedright\strut
Female (n:454) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.11\columnwidth}\raggedright\strut
Male (n:513) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.11\columnwidth}\raggedright\strut
p**\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Height, cm\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
170.8\selectlanguage{ngerman}±8.9\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
169.1\selectlanguage{ngerman}±8.8\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
167.8\selectlanguage{ngerman}±9.2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
167.6\selectlanguage{ngerman}±8.6\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
166\selectlanguage{ngerman}±6.6\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
175\selectlanguage{ngerman}±6.8\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.013\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Weight, kg\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
69.1\selectlanguage{ngerman}±11.7\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
71\selectlanguage{ngerman}±11.2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
72.4\selectlanguage{ngerman}±10.2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
73.2\selectlanguage{ngerman}±10.4\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
68.4\selectlanguage{ngerman}±8.7\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
73.6\selectlanguage{ngerman}±9.1\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.106\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Body mass index, kg/m\selectlanguage{ngerman}²\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
23.6\selectlanguage{ngerman}±2.8\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
25\selectlanguage{ngerman}±2.8\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
25.4\selectlanguage{ngerman}±2.7\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
25.9\selectlanguage{ngerman}±3.2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
24.4\selectlanguage{ngerman}±3.45\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
24.9\selectlanguage{ngerman}±2.5\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.129\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Body surface area, m\selectlanguage{ngerman}²\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
1.9\selectlanguage{ngerman}±0.5\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
2\selectlanguage{ngerman}±0.6\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
2.1\selectlanguage{ngerman}±0.6\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
2.1\selectlanguage{ngerman}±0.7\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.024\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
1.69\selectlanguage{ngerman}±0.2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
1.87\selectlanguage{ngerman}±0.2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.058\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Systolic blood pressure, mmHg\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
112.3\selectlanguage{ngerman}±11.4\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
115.9\selectlanguage{ngerman}±10.7\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
118.9\selectlanguage{ngerman}±10.4\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
120.3\selectlanguage{ngerman}±10.1\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
113.9\selectlanguage{ngerman}±11.7\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
116.8\selectlanguage{ngerman}±11.1\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.089\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Diastolic blood pressure, mmHg\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
69.9\selectlanguage{ngerman}±9\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
73.2\selectlanguage{ngerman}±8.3\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
73.8\selectlanguage{ngerman}±8.4\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
75.5\selectlanguage{ngerman}±8.1\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
71.4\selectlanguage{ngerman}±8.7\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
72.6\selectlanguage{ngerman}±8.5\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.183\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Glycaemia, mg/dL\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
90.4\selectlanguage{ngerman}±9\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
94.1\selectlanguage{ngerman}±9.1\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
95.6\selectlanguage{ngerman}±9.5\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
97.9\selectlanguage{ngerman}±8\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
92\selectlanguage{ngerman}±10\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
93\selectlanguage{ngerman}±11\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.396\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Serum creatinine, mg/dL\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.71\selectlanguage{ngerman}±0.11\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.81\selectlanguage{ngerman}±0.15\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.83\selectlanguage{ngerman}±0.17\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.85\selectlanguage{ngerman}±0.18\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.521\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.76\selectlanguage{ngerman}±0.13\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.84\selectlanguage{ngerman}±0.14\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.198\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Hemoglobin, g/dL\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
14.9\selectlanguage{ngerman}±1.3\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
14.8\selectlanguage{ngerman}±1.3\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
14.5\selectlanguage{ngerman}±1.4\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
14.3\selectlanguage{ngerman}±1.3\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.763\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
13.5\selectlanguage{ngerman}±1.4\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
15.1\selectlanguage{ngerman}±1.4\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.349\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Total cholesterol, mg/dL\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
151.2\selectlanguage{ngerman}±18.3\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
158.2\selectlanguage{ngerman}±19\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
164.5\selectlanguage{ngerman}±22.3\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
173.4\selectlanguage{ngerman}±24.3\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
163\selectlanguage{ngerman}±27\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
165\selectlanguage{ngerman}±26\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.037\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Low-density lipoprotein (LDL)\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
92.1\selectlanguage{ngerman}±21.4\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
105.7\selectlanguage{ngerman}±24.6\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
111.8\selectlanguage{ngerman}±26.7\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
114.5\selectlanguage{ngerman}±27.9\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
105.3\selectlanguage{ngerman}±24\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
106.6\selectlanguage{ngerman}±25.4\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.049\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
High-density lipoprotein, mg/dL\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
49.4\selectlanguage{ngerman}±11.5\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
48.5\selectlanguage{ngerman}±11.2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
47.9\selectlanguage{ngerman}±10.5\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
47.4\selectlanguage{ngerman}±10.1\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.693\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
47.9\selectlanguage{ngerman}±11.2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
44.3\selectlanguage{ngerman}±10.3\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.003\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Triglyceride, mg/dL\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
104.5\selectlanguage{ngerman}±32\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
112.2\selectlanguage{ngerman}±33\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
118.1\selectlanguage{ngerman}±34\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
120.4\selectlanguage{ngerman}±31\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.031\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
107.4\selectlanguage{ngerman}±32.7\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
114.8\selectlanguage{ngerman}±35.7\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.009\strut
\end{minipage}\tabularnewline
\bottomrule
\end{longtable}\selectlanguage{english}
\begin{longtable}[]{@{}llllllllllllll@{}}
\toprule
\begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-2 Mitral valve Pulse Doppler velocities and left atrial volume
index (LAVI)\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-2 Mitral valve Pulse Doppler velocities and left atrial volume
index (LAVI)\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-2 Mitral valve Pulse Doppler velocities and left atrial volume
index (LAVI)\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-2 Mitral valve Pulse Doppler velocities and left atrial volume
index (LAVI)\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-2 Mitral valve Pulse Doppler velocities and left atrial volume
index (LAVI)\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-2 Mitral valve Pulse Doppler velocities and left atrial volume
index (LAVI)\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-2 Mitral valve Pulse Doppler velocities and left atrial volume
index (LAVI)\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-2 Mitral valve Pulse Doppler velocities and left atrial volume
index (LAVI)\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-2 Mitral valve Pulse Doppler velocities and left atrial volume
index (LAVI)\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-2 Mitral valve Pulse Doppler velocities and left atrial volume
index (LAVI)\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-2 Mitral valve Pulse Doppler velocities and left atrial volume
index (LAVI)\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-2 Mitral valve Pulse Doppler velocities and left atrial volume
index (LAVI)\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-2 Mitral valve Pulse Doppler velocities and left atrial volume
index (LAVI)\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-2 Mitral valve Pulse Doppler velocities and left atrial volume
index (LAVI)\strut
\end{minipage}\tabularnewline
\midrule
\endhead
\begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
18-29 years (n:341) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
18-29 years (n:341) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
18-29 years (n:341) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
30-39 years (n:314) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
30-39 years (n:314) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
30-39 years (n:314) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
40-49 years (n:202) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
40-49 years (n:202) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
40-49 years (n:202) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
[?]50 years (n:110) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
[?]50 years (n:110) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
[?]50 years (n:110) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
p*\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Female\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Male\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
p**\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Female\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Male\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
p**\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Female\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Male\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
p**\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Female\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Male\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
p**\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
E wave velocity, cm/s\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.88\selectlanguage{ngerman}±0.14\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.84\selectlanguage{ngerman}±0.13\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.024\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.86\selectlanguage{ngerman}±0.15\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.82\selectlanguage{ngerman}±0.13\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.036\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.80\selectlanguage{ngerman}±0.11\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.78\selectlanguage{ngerman}±0.1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.042\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.78\selectlanguage{ngerman}±0.1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.76\selectlanguage{ngerman}±0.11\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.034\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
A wave velocity, cm/s\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.58\selectlanguage{ngerman}±0.1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.57\selectlanguage{ngerman}±0.1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.031\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.6\selectlanguage{ngerman}±0.11\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.58\selectlanguage{ngerman}±0.1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.029\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.62\selectlanguage{ngerman}±0.1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.59\selectlanguage{ngerman}±0.11\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.049\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.64\selectlanguage{ngerman}±0.11\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.59\selectlanguage{ngerman}±0.1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.045\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
E wave deceleration time, ms\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
178\selectlanguage{ngerman}±48\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
181\selectlanguage{ngerman}±51\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
184\selectlanguage{ngerman}±45\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
186\selectlanguage{ngerman}±43\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
188\selectlanguage{ngerman}±44\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
190\selectlanguage{ngerman}±43\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
201\selectlanguage{ngerman}±47\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
209\selectlanguage{ngerman}±46\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
E/A ratio\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1.65\selectlanguage{ngerman}±0.49\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1.61\selectlanguage{ngerman}±0.49\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.038\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1.45\selectlanguage{ngerman}±0.4\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1.42\selectlanguage{ngerman}±0.41\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.03\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1.41\selectlanguage{ngerman}±0.44\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1.4\selectlanguage{ngerman}±0.45\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.041\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1.26\selectlanguage{ngerman}±0.46\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
1.24\selectlanguage{ngerman}±0.43\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.031\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Left atrial volume index, mL/m\selectlanguage{ngerman}²\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
18.7\selectlanguage{ngerman}±2.8\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
19.2\selectlanguage{ngerman}±2.7\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.048\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
19.9\selectlanguage{ngerman}±2.9\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
20.9\selectlanguage{ngerman}±2.8\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.018\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
21.7\selectlanguage{ngerman}±3\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
22.6\selectlanguage{ngerman}±2.8\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.027\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
23.4\selectlanguage{ngerman}±2.7\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
24.7\selectlanguage{ngerman}±2.4\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.042\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage}\tabularnewline
\bottomrule
\end{longtable}\selectlanguage{english}
\begin{longtable}[]{@{}llllllllllllll@{}}
\toprule
\begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-3 Data about left ventricular tissue Doppler\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-3 Data about left ventricular tissue Doppler\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-3 Data about left ventricular tissue Doppler\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-3 Data about left ventricular tissue Doppler\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-3 Data about left ventricular tissue Doppler\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-3 Data about left ventricular tissue Doppler\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-3 Data about left ventricular tissue Doppler\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-3 Data about left ventricular tissue Doppler\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-3 Data about left ventricular tissue Doppler\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-3 Data about left ventricular tissue Doppler\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-3 Data about left ventricular tissue Doppler\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-3 Data about left ventricular tissue Doppler\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-3 Data about left ventricular tissue Doppler\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-3 Data about left ventricular tissue Doppler\strut
\end{minipage}\tabularnewline
\midrule
\endhead
\begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
18-29 years (n:341) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
18-29 years (n:341) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
18-29 years (n:341) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
30-39 years (n:314) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
30-39 years (n:314) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
30-39 years (n:314) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
40-49 years (n:202) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
40-49 years (n:202) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
40-49 years (n:202) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
[?]50 years (n:110) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
[?]50 years (n:110) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
[?]50 years (n:110) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
p*\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Female\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Male\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
p**\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Female\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Male\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
p**\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Female\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Male\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
p**\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Female\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Male\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
p**\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Septal e' wave, cm/s\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
11.9\selectlanguage{ngerman}±2.3\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
11.7\selectlanguage{ngerman}±2\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
11.1\selectlanguage{ngerman}±2.1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
10.7\selectlanguage{ngerman}±1.9\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
8.9\selectlanguage{ngerman}±1.7\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
8.4\selectlanguage{ngerman}±1.5\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
8\selectlanguage{ngerman}±1.4\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
7.7\selectlanguage{ngerman}±1.5\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Septal a' wave, cm/s\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
8.6\selectlanguage{ngerman}±1.5\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
8.9\selectlanguage{ngerman}±1.8\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
9.1\selectlanguage{ngerman}±1.6\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
9.4\selectlanguage{ngerman}±1.8\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
9.5\selectlanguage{ngerman}±1.4\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
9.9\selectlanguage{ngerman}±1.6\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
10.1\selectlanguage{ngerman}±1.5\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
10.5\selectlanguage{ngerman}±1.4\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Septal s' wave, cm/s\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
8.9\selectlanguage{ngerman}±1.3\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
8.6\selectlanguage{ngerman}±1.2\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
8.4\selectlanguage{ngerman}±1.2\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
8\selectlanguage{ngerman}±1.3\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
7.8\selectlanguage{ngerman}±1.4\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
7.7\selectlanguage{ngerman}±1.3\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.671\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
7.4\selectlanguage{ngerman}±1.3\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
7.3\selectlanguage{ngerman}±1.4\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.748\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Lateral e' wave, cm/s\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
13.1\selectlanguage{ngerman}±3.1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
12.7\selectlanguage{ngerman}±3\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
11.9\selectlanguage{ngerman}±2.9\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
10.6\selectlanguage{ngerman}±2.7\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
10.4\selectlanguage{ngerman}±2.6\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
9.7\selectlanguage{ngerman}±2.4\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
9.6\selectlanguage{ngerman}±2.1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
9.3\selectlanguage{ngerman}±2\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Lateral a' wave, cm/s\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
8.6\selectlanguage{ngerman}±1.9\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
8.9\selectlanguage{ngerman}±2.1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
8.9\selectlanguage{ngerman}±2\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
9.5\selectlanguage{ngerman}±2.2\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
9.4\selectlanguage{ngerman}±1.8\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
9.9\selectlanguage{ngerman}±1.9\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
9.7\selectlanguage{ngerman}±1.6\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
10.4\selectlanguage{ngerman}±1.7\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Lateral s' wave, cm/s\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
10.7\selectlanguage{ngerman}±2.1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
10.9\selectlanguage{ngerman}±2.4\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.067\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
10.2\selectlanguage{ngerman}±2.1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
10.5\selectlanguage{ngerman}±2.3\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.054\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
9.9\selectlanguage{ngerman}±1.9\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
10.2\selectlanguage{ngerman}±2\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.098\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
9.7\selectlanguage{ngerman}±1.8\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
9.9\selectlanguage{ngerman}±1.9\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.047\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.049\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Lateral E/e'\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
5.7\selectlanguage{ngerman}±1.5\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
5.6\selectlanguage{ngerman}±1.5\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.029\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
6.6\selectlanguage{ngerman}±1.7\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
6.3\selectlanguage{ngerman}±1.6\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.014\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
7.4\selectlanguage{ngerman}±1.7\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
7\selectlanguage{ngerman}±1.7\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.016\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
7.9\selectlanguage{ngerman}±2\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
7.7\selectlanguage{ngerman}±1.9\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.035\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.538\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Septal E/e'\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
6.6\selectlanguage{ngerman}±1.5\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
6.3\selectlanguage{ngerman}±1.6\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.028\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
7.1\selectlanguage{ngerman}±1.7\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
6.9\selectlanguage{ngerman}±1.6\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.032\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
8.6\selectlanguage{ngerman}±2\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
8.3\selectlanguage{ngerman}±2.1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.019\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
9.6\selectlanguage{ngerman}±2.2\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
9.3\selectlanguage{ngerman}±2.2\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.028\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.598\strut
\end{minipage}\tabularnewline
\bottomrule
\end{longtable}\selectlanguage{english}
\begin{longtable}[]{@{}llllllllllllll@{}}
\toprule
\begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-4 Right ventricular Tissue Doppler datas\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-4 Right ventricular Tissue Doppler datas\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-4 Right ventricular Tissue Doppler datas\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-4 Right ventricular Tissue Doppler datas\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-4 Right ventricular Tissue Doppler datas\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-4 Right ventricular Tissue Doppler datas\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-4 Right ventricular Tissue Doppler datas\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-4 Right ventricular Tissue Doppler datas\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-4 Right ventricular Tissue Doppler datas\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-4 Right ventricular Tissue Doppler datas\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-4 Right ventricular Tissue Doppler datas\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-4 Right ventricular Tissue Doppler datas\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-4 Right ventricular Tissue Doppler datas\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Table-4 Right ventricular Tissue Doppler datas\strut
\end{minipage}\tabularnewline
\midrule
\endhead
\begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
18-29 years (n:341) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
18-29 years (n:341) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
18-29 years (n:341) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
30-39 years (n:314) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
30-39 years (n:314) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
30-39 years (n:314) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
40-49 years (n:202) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
40-49 years (n:202) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
40-49 years (n:202) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
[?]50 years (n:110) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
[?]50 years (n:110) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
[?]50 years (n:110) Mean\selectlanguage{ngerman}±SD\strut
\end{minipage} & \begin{minipage}[t]{0.07\columnwidth}\raggedright\strut
p*\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Female\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Male\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
p**\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Female\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Male\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
p**\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Female\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Male\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
p**\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Female\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
Male\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
p**\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
s' wave, cm/s\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
12.9\selectlanguage{ngerman}±2.1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
13.2\selectlanguage{ngerman}±2.5\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.198\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
12.6\selectlanguage{ngerman}±2.2\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
12.9\selectlanguage{ngerman}±2.4\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.234\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
12.1\selectlanguage{ngerman}±2.5\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
12.5\selectlanguage{ngerman}±2.6\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.224\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
11.8\selectlanguage{ngerman}±2.5\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
12.2\selectlanguage{ngerman}±2.3\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.198\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.172\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
e' wave, cm/s\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
14.8\selectlanguage{ngerman}±3.4\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
14.1\selectlanguage{ngerman}±3.1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.072\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
14.2\selectlanguage{ngerman}±3.3\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
13.7\selectlanguage{ngerman}±3.1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.198\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
13.5\selectlanguage{ngerman}±3.1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
12.9\selectlanguage{ngerman}±3.2\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.091\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
11.7\selectlanguage{ngerman}±3.3\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
11.6\selectlanguage{ngerman}±3.2\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.547\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
a' wave, cm/s\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
11.7\selectlanguage{ngerman}±3.1\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
11.5\selectlanguage{ngerman}±3\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.481\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
12.7\selectlanguage{ngerman}±3.2\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
12.5\selectlanguage{ngerman}±3.3\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.201\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
13.8\selectlanguage{ngerman}±3.4\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
13.5\selectlanguage{ngerman}±3.5\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.187\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
15\selectlanguage{ngerman}±3.5\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
14.7\selectlanguage{ngerman}±3.6\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
0.328\strut
\end{minipage} & \begin{minipage}[t]{0.05\columnwidth}\raggedright\strut
\textless{}0.001\strut
\end{minipage}\tabularnewline
\bottomrule
\end{longtable}\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/image1/image1}

\end{center}
\end{figure}

Figure-1 ; Mean E/A ratios according to ages\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/image2/image2}

\end{center}
\end{figure}

Figure-2 ; Average of septal and lateral E/e' ratio according to ages\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/image3/image3}

\end{center}
\end{figure}\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/image4/image4}

\end{center}
\end{figure}

Figure-3 ; Intraclass correlation coefficient value was 0.965 (95\% CI:
0.975--0.992; P\textless{}0.001)

\selectlanguage{english}
\FloatBarrier
\end{document}

