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\begin{document}

\title{Acute Myeloid Leukemia with Monosomy 7 in Sickle Cell Disease Post T
Cell Replete Haploidentical Hematopoietic Stem Cell Transplant: Brief
Report}



\author[1]{Archana Rauthan}%
\author[1]{Atish Bakane}%
\author[1]{Gaurav Kharya}%
\affil[1]{Indraprastha Apollo Hospital}%


\vspace{-1em}



  
  \date{May 18, 2024}


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\selectlanguage{english}
\begin{abstract}
Hematopoietic Stem Cell Transplant (HSCT) is increasingly being used as
a curative treatment for various malignant and non-malignant conditions.
Second malignancies are known long term complication post HSCT. Myeloid
malignancies rarely occur post allogenic HSCT. To the best of our
knowledge there are no reported case of myeloid malignancy occurring in
sickle cell disease (SCD) patient post haploidentical HSCT. We report 2
patients with SCD, who developed Acute Myeloid Leukemia (AML) with
monosomy 7 post HSCT. Long-term follow-up is needed post allogenic HSCT
even if done for benign conditions like SCD with no prior chemotherapy
or malignancy history.%
\end{abstract}%



\sloppy


\textbf{Acute Myeloid Leukemia with Monosomy 7 in Sickle Cell Disease
Post T Cell Replete Haploidentical Hematopoietic Stem Cell Transplant:
Brief Report}

Archana Rauthan\textsuperscript{1}, Atish Bakane\textsuperscript{1},
Gaurav Kharya\textsuperscript{1*}

Centre for Bone Marrow Transplant and Cellular Therapies, Indraprastha
Apollo Hospital, New Delhi India

*Correspondence to: Gaurav Kharya @ gaurav.kharya@gmail.com; Ph:
+919213132168

Address:

Office: Clinical Lead, Center for Bone Marrow Transplant \& Cellular
Therapy, Indraprastha Apollo Hospital, New Delhi, India

Residence: C57 Y3, C Block, Dilshad Garden, Shahadra, Delhi, 110095

Word Count:

Abstract: 98

Main text: 1383

Tables: 1

Figures: 0

Running title: AML with monosomy 7 in SCD post HSCT

Key words: Sickle cell disease, HSCT, AML, monosomy 7, secondary
malignancy

Abbreviations:\selectlanguage{english}
\begin{longtable}[]{@{}ll@{}}
\toprule
HSCT & Hematopoietic stem cell transplant\tabularnewline
\midrule
\endhead
SCD & Sickle cell disease\tabularnewline
AML & Acute myeloid leukemia\tabularnewline
tAML/MDS & treatment related acute myeloid leukemia/
Myelodysplasia\tabularnewline
DSA & Donor specific antibody\tabularnewline
TBI & Total body irradiation\tabularnewline
GvHD & Graft versus host disease\tabularnewline
PO & Per oral\tabularnewline
MMF & Mycophenolate mofetil sodium\tabularnewline
GCSF & Granulocyte colony stimulating factor\tabularnewline
PBSC & Peripheral blood stem cells\tabularnewline
rBW & Recipient body weight\tabularnewline
TLC & Total leucocyte count\tabularnewline
ANC & Absolute neutrophil count\tabularnewline
CBC & Complete blood count\tabularnewline
BMT & Bone marrow examination\tabularnewline
Ara-C & Cytosine arabinoside\tabularnewline
SMN & Secondary malignant neoplasms\tabularnewline
PTLD & Post-transplant lymphoproliferative disorder\tabularnewline
EBV & Epstein barr virus\tabularnewline
HSC & Hematopoietic stem cells\tabularnewline
MAC/RIC & Myeloablative/reduced intensity conditioning\tabularnewline
EBMT & European Society for Blood and Marrow
Transplantation\tabularnewline
\bottomrule
\end{longtable}

\textbf{DR GAURAV KHARYA}

CLINICAL LEAD \textbar{} CENTER FOR BONE MARROW TRANSPLANT AND CELLULAR
THERAPIES

SENIOR CONSULTANT \textbar{} PEDIATRIC HEMATOLOGY ONCOLOGY AND
IMMUNOLOGY

APOLLO HOSPITAL, SARITA VIHAR, DELHI 110076

Email:\emph{gaurav.kharya@gmail.com}; Phone: +919213132168

\textbf{Hosted file}

\verb`AML post HSCT in SCD.docx`  available at \url{https://authorea.com/users/328288/articles/455660-acute-myeloid-leukemia-with-monosomy-7-in-sickle-cell-disease-post-t-cell-replete-haploidentical-hematopoietic-stem-cell-transplant-brief-report}

\selectlanguage{english}
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\end{document}

