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Number of figures: 1
Keywords: IgE; mast cells; protection; Staphylococcusaureus; allergy; murine models; pediatrics, transplacental transfer, toxin hypothesis.
Abbreviations: CXCL1/2, chemokine (C-X-C motif) ligand 1/2; FcεRI, high-affinity receptor for the Fc region of IgE; FcRN, neonatal Fc receptor; MC, mast cell; SA, Staphylococcus aureus ; sIgE, specific immunoglobulin E; Tfh13, T follicular helper 13; TNF, tumor necrosis factor.
Statement of conflict of interest: the authors declare no conflict of interest in relation to this work.
Statement of contribution : LV and MG conceptualized the article and wrote the manuscript. IEG supervised the work of the rest of the authors and reviewed the final version of the article.
Statement of funding : This work was supported by the Instituto de Salud Carlos III of the Spanish Ministry of Science and Competitiveness (grants co-funded by the European Regional Development Fund) through the research contract “Juan Rodes” for IEG (JR19/00029), and the program of Redes Temáticas de Investigación Colaborativa en Salud (RETICS): Asma, Reacciones Adversas y Alérgicas-ARADyAL (RD16/0006/0001).
Ethical approval and trial registration: Not applicable.
Consent for publication: Not applicable.
Data sharing and data accessibility: Not applicable.
Acknowledgements: The authors want to thank Dr. Anna Globinska for Figure 1 design and Dr. Jiménez-Saiz for critical review of the manuscript.
Abstract: Not applicable.