6.3.b. Tolerance
Current data highlight the importance of a thorough allergy work-up to find safe alternative PPIs. Because of the high cross-reactivity rates among PPIs (Table 5), a safe alternative PPI should only be recommended after a complete drug allergy work-up (iskin testing followed by DPT in case of negative results). The PPI to be tested as a safe alternative, may be selected according to the cross-reactivity rates reported in the literature and listed in table 6).