Stratified analyses by geographical region
sIgE to peanut was highly sensitive in North America (94%) but
presented lower sensitivities in Asia (75%), Australia (80%), Northern
Europe (77%) and Western Europe (59%). Ara h 2 was highly specific in
Australia (97%), Northern Europe (99%) and Western Europe (92%) but
lower in Asian populations (79%). For the diagnosis of CMA, SPT and
sIgE had a lower performance in Asian populations. SPT and sIgE had a
lower specificity in Asia (74% and 89%) compared to Southern Europe
(82% and 96%). For wheat allergy diagnostic accuracy of sIgE was also
lower in Asia with a specificity of 73% vs 87% in Northern Europe.
Overall, diagnostic tests showed variability according to geographical
regions, more details can be seen in Table 7.
A summary of the diagnostic tests and its accuracy is shown in Table 8.