What is the relationship between clinical manifestations
and SARS-CoV-2 seroconversion?
The antibody response occurs later than initiation of symptoms as well
as of the detection of viral RNA by RT-PCR in respiratory tract
specimens, which usually peaks within the first week of symptom onset
(Figure 2 ). Although antibodies to SARS-CoV-2 have been
detected as early as the first week after symptom onset, IgM, IgA and
IgG seroconversion commonly occurs between the 2nd and
3rd week of clinical illness onset. Thereafter, IgM
starts to decline, reaching low levels by week 5 and almost disappears
by week 7, while IgA and IgG persist beyond this
period.33,96,100