What is the relationship between clinical manifestations and SARS-CoV-2 seroconversion?
The antibody response occurs later than initiation of symptoms as well as of the detection of viral RNA by RT-PCR in respiratory tract specimens, which usually peaks within the first week of symptom onset (Figure 2 ). Although antibodies to SARS-CoV-2 have been detected as early as the first week after symptom onset, IgM, IgA and IgG seroconversion commonly occurs between the 2nd and 3rd week of clinical illness onset. Thereafter, IgM starts to decline, reaching low levels by week 5 and almost disappears by week 7, while IgA and IgG persist beyond this period.33,96,100