Does metabolic fitness at the cellular and individual
level affect COVID-19?
Systemic dysregulation of metabolism, such as that seen in obesity and
diabetes is a risk factor of SARS-CoV-1 and SARS-CoV-2 infection and of
COVID-19 severity58. These diseases lead to chronic
systemic inflammation, upregulation of SARS-CoV-2 receptors in the lungs
and the periphery, and they disturb the glucose and lipid metabolism of
tissues and immune cells.14,77,78