Of the drugs being assessed for COVID-19 treatment, which ones are more immunogenic or associated with hypersensitivity reactions?
Immunomodulatory drugs (including azithromycin), hydroxychloroquine/chloroquine and IFNs, are the ones most frequently involved in hypersensitivity reactions. Most reactions are non-immediate and further studies are required to clarify whether this increased frequency is caused by the drug immunogenicity or simply derives from a greater consumption as compared to other treatments.146