Variables Univariable Univariable Multivariable Multivariable
HR (95%CI) P-value HR (95%CI) P-value
ACT regimen 1.88 (1.07-3.28) 0.03 1.97 (1.12-3.50) 0.02
Age ≥65 years 0.99 (0.36-2.72) 0.98
Age ≥75 years 1.52 (0.86-2.69) 0.15 1.76 (0.98-3.15) 0.06
Female gender 0.89 (0.53-1.49) 0.65
Body mass index 0.99 (0.95-1.04) 0.78
Congestive heart failure 1.08 (0.63-1.84) 0.78
Hypertension 0.78 (0.33-1.80) 0.56
Diabetes mellitus 1.31 (0.79-2.19) 0.29
Prior stroke/TIA/SE 1.25 (0.71-2.18) 0.44
Vascular disease 0.98 (0.59-1.63) 0.95
Renal dysfunction 1.10 (0.44-2.74) 0.84
Liver dysfunction 1.76 (0.87-3.57) 0.12 1.25 (0.51-3.08) 0.63
History of bleeding 2.23 (0.89-5.56) 0.09 2.08 (0.83-5.20) 0.12
Labile INR 1.37 (0.50-3.76) 0.55
Alcohol intake >8 U/week 1.74 (0.86-3.52) 0.13 1.66 (0.68-4.05) 0.27