Variables All (n=524) DAPT (n=220) ACT (n=304) P-value
Demographics and clinical features Demographics and clinical features Demographics and clinical features Demographics and clinical features Demographics and clinical features
Age at LAAC (years), mean ± SD 76.6±7.6 78.4±7.2 75.3±7.7 <0.01
Body mass index (kg/m²), mean ± SD 29.3±5.8 29.3±6.3 28.3±5.4 0.95
Female sex, n (%) 114 (21.8) 75 (34.1) 99 (32.6) 0.78
Coronary artery disease, n (%) 273 (52.1) 126 (57.3) 147 (48.4) 0.05
Prior PCI/CAGB, n (%) 220 (42.0) 95 (43.2) 125 (41.1) 0.65
Serum creatinine level (mg/dl), mean ± SD 1.4±0.7 1.3±0.8 1.4±0.7 0.12
Paroxysmal AF, n (%) 182 (36.1) 79 (35.9) 103 (33.9) 0.64
LV ejection fraction, % 54.7±10.4 52.4±12.2 56.4±8.6 <0.01
Stroke risk Stroke risk Stroke risk Stroke risk Stroke risk
CHA2DS2-VASc score, mean ± SD 4.6±1.6 4.8±1.5 4.5±1.7 0.01
CHADS2 score, mean ± SD 3.0±1.1 3.0±1.1 3.0±1.2 0.70
Prior stroke/TIA/Systemic embolism, n (%) 123 (23.5) 44 (20.0) 79 (26.0) 0.12
Congestive heart failure, n (%) 167 (31.9) 78 (35.5) 89 (29.3) 0.15
Arterial hypertension, n (%) 485 (92.6) 207 (94.1) 278 (91.5) 0.31
Age ≥75 years, n (%) 347 (66.2) 166 (75.5) 181 (59.5) <0.01
Vascular disease, n (%) 324 (61.8) 137 (62.3) 187 (61.5) 0.93
Diabetes mellitus, n (%) 173 (33.0) 75 (34.1) 98 (32.2) 0.71
Bleeding risk Bleeding risk Bleeding risk Bleeding risk Bleeding risk
HAS-BLED score, mean ± SD 3.3±0.9 3.3±0.7 3.4±1.0 0.68
Age ≥65 years, n (%) 492 (93.9) 216 (98.2) 276 (90.8) <0.01
History of hemorrhagic/bleeding tendencies, n (%) 435 (83.8) 184 (83.6) 255 (83.9) >0.99
Prior bleeding (≥major), n (%) 309 (59.0) 142 (64.6) 167 (54.9) 0.03
Intracranial, n (%) 41 (7.8) 13 (5.9) 28 (9.2) 0.19
Gastrointestinal, n (%) 149 (28.4) 62 (28.2) 87 (28.6) 0.92
Other site, n (%) 119 (22.7) 67 (30.5) 52 (17.1) <0.01
Arterial hypertension ≥160mmHg, n (%) 41 (7.8) 18 (8.2) 23 (7.6) 0.87
Renal dysfunction, n (%) 40 (7.6) 11 (5.0) 29 (9.5) 0.07
Liver dysfunction, n (%) 47 (9.0) 9 (4.1) 38 (12.5) <0.01
Labile INR, n (%) 26 (5.0) 13 (5.9) 13 (4.3) 0.42
Drugs with predisposition to bleeding, n (%) 489 (93.3) 214 (97.3) 275 (90.5) <0.01
Alcohol intake >8 U/week, n (%) 49 (9.4) 17 (7.7) 32 (10.5) 0.29