Missing information
The comprehensive and prospective registration of clinical trials has been internationally supported since 2004 as a way to reduce the selective publication of studies and the selective reporting of outcomes.30 Since the early years of clinical trial registration, ensuring that the registered data are complete and accurate has been a challenging objective of multiple enforcement mechanisms, including legal requirements.26, 30Remarkably, approximately one-third of the registered RCTs included in this study had at least one piece of missing information, either related to treatment dose, duration, timeframes of outcome assessment or the lack of definition of a safety outcome. This is of particular concern amid the current pandemic scenario where the rush to test any potential helpful drug may pose a risk that low-quality evidence may be used to support clinical decisions with unpredictable impacts to patients and the health system.