Data analysis
Characteristics of the design of the RCTs were summarized according to the number trial registers documenting clinical or surrogate outcomes and describing data ascertainment methods to detect adverse events. Simple proportions were reported for dichotomous outcomes. For continuous data, means and standard deviations (SD) or medians and interquartile ranges (IQR) were reported, as appropriate. Comparisons between continuous variables were made using t-test and reporting the mean difference (MD) with 95% confidence intervals (CI).