CONCLUSION
Presently, the diagnosis of SARS coronaviruses have been exclusively on the basis of rRT-PCR and serology and none of these methods is solely reliable at early stage of the diseases. Specific methods for early diagnosis of SARS-CoVs are very crucial in order to effectively control and manage epidemics. Sensitivity and specificity of IgG-IgM RDT kits were found to be acceptable as they are speedy, easy to use and cheap procedures which contribute to their application in mass testing. However, they cannot be employed instead of rRT-PCR to detect COVID-19 but can be optional and complementary test. Development of rRT-PCR/IgG-IgM combined test kit could be helpful to ease diagnosis and management of epidemics, therefore more efforts are needed to investigate alternative diagnostics for coronaviruses.