CONCLUSION
Presently, the diagnosis of SARS coronaviruses have been exclusively on
the basis of rRT-PCR and serology and none of these methods is solely
reliable at early stage of the diseases. Specific methods for early
diagnosis of SARS-CoVs are very crucial in order to effectively control
and manage epidemics. Sensitivity and specificity of IgG-IgM RDT kits
were found to be acceptable as they are speedy, easy to use and cheap
procedures which contribute to their application in mass testing.
However, they cannot be employed instead of rRT-PCR to detect COVID-19
but can be optional and complementary test. Development of
rRT-PCR/IgG-IgM combined test kit could be helpful to ease diagnosis and
management of epidemics, therefore more efforts are needed to
investigate alternative diagnostics for coronaviruses.