Study design
Participants received a single intravenous infusion of phosphocreatine
sodium according to their age (28 days ~ < 1
year old: 0.5 g, 1~ < 6 years old: 1 g, 6
~ < 18 years old: 2 g). The above
phosphocreatine sodium was dissolved in 50 ml 0.9% sodium chloride
injection and continuously injected with an intravenous pump within 30 ±
2 min. Blood samples from the arm without an intravenous infusion were
collected at baseline (before infusion) and, approximately 30, 40 or 50,
75 and 180 min after the start of infusion. The actual infusion time and
sampling time were recorded. The blood samples were centrifuged at
4oC (3000 rpm) for 10 min, and the plasma at upper
layer was separated and stored immediately at -40˚C until analysis.