Simulation
The final PCr and Cr joint population pharmacokinetic model was used to simulate different regimens for pediatric patients with myocarditis. Pediatric patients were divided into different subgroups in accordance with age (Group1:28 days ~ < 1 year old; Group2: 1~ < 6 years old; Group3: 6 ~ < 18 years old). Dose followed the dosage guideline of this trial (Group1: 0.5 g, Group2: 1 g, Group3: 2 g). Monte Carlo simulations were carried out to find the concentration curve under continuous drug administration. The simulated regimens are as follows:
Regimen1: the drug was intravenous administered once a day with infusion time of 30 min for each infusion. The administration interval was 24 h and drug was administered continuously for 4 days.
Regimen2: the drug was intravenous administered twice a day with infusion time of 30 min for each infusion. The administration interval was 12 h and drug was administered continuously for 4 days.
Regimen3: the drug was intravenous administered twice a day with infusion time of 300 min for each infusion. The administration interval was 12 h and drug was administered continuously for 4 days.
Regimen4: the drug was intravenous administered twice a day with infusion time of 600 min for each infusion. The administration interval was 12 h and drug was administered continuously for 4 days.