Patient characteristics
A total of 100 pediatric patients (56 males and 44 females) with a median age of 5.78 years old (range from 0.38 to 16.45 years old) and a median BW of 20.4 kg (range from 7.9 to 86 kg) were enrolled in this study. Participant demographic characteristics are shown in Table 1 . A total of 997 plasma concentrations (498 for PCr and 499 for Cr) were included in the analysis. Approximately 48.7% of the PCr concentrations were below LLOQ and were handled using the M3 method [17]. All the Cr concentrations were above LLOQ. The baseline covariates information in this data set are shown in Supplemental Material 1 .