Patient characteristics
A total of 100 pediatric patients
(56
males and 44 females) with a median age of 5.78 years old (range from
0.38 to 16.45 years old) and a median BW of 20.4 kg (range from 7.9 to
86 kg) were enrolled in this study. Participant demographic
characteristics are shown in Table 1 . A total of 997 plasma
concentrations (498 for PCr and 499 for Cr) were included in the
analysis. Approximately 48.7% of the PCr concentrations were below LLOQ
and were handled using the M3 method [17]. All the Cr concentrations
were above LLOQ. The baseline covariates information in this data set
are shown in Supplemental Material 1 .