Simulation
The simulation results showed that the PCr had no accumulation in vivo. Under the regimen1 and 2, the PCr was basically eliminated within 3 hours (the concentration of 50th quantile of 1000 simulations was less than 0.1 μmol/L). Increasing infusion time (regimen3 and 4) could prolong the residence time of PCr in vivo and maintain a certain concentration of PCr. With the infusion of PCr, the concentration of Cr in vivo increased rapidly. In regimen1 and 2, Cr was basically eliminated to the baseline level after 12h (the concentration of 50th quantile in 1000 simulated profiles was similar to the baseline level 67 μmol/L). The simulation curves are shown in Supplemental Material 2 .