Results
A total of 997 plasma concentrations (498 for PCr and 499 for Cr) were
included in the analysis. A four-compartment chain model (central and
peripheral compartments for both PCr and Cr) with first-order
elimination adequately characterized the in vivo process of PCr and Cr.
Allometric scaling based on bodyweight was applied to the PK parameters.
The covariate analysis identified that the glomerular filtration rate
(GFR) was strongly associated with the Cr clearance. Bootstrap and
visual predictive check suggested a robust and reliable pharmacokinetic
model was developed. The simulation results showed that the PCr had no
accumulation in vivo. With the infusion of PCr, the concentration of Cr
increased rapidly.