Subject selection
This study was conducted at Beijing Children’s Hospital, Capital Medical
University. Inclusion criteria were (1) age less than 18 years old, (2)
boys or girls, (3) clinically diagnosed pediatric myocarditis and (4)
the acute stage in the clinical stage of myocarditis. The main exclusion
criteria were as follows: allergy to Phosphocreatine Sodium, other
causes of myocardial injury, a history of heart disease, other serious
illnesses, other causes of electrocardiogram changes, participated in
other clinical trials prior to screening and patients with renal
insufficiency. The baseline
information included gender, age (year), height (cm), bodyweight (BW,
kg), disease duration, white blood cell count (WBC), red blood cell
count (RBC), hemoglobin (HGB), blood platelet count (PLT), percentage of
neutrophils (NEUT), lymphocyte percentage (LYMPH), percentage of
monocytes (MONO), percentage of eosinophilic cells (EO), percentage of
basophilic cells (BASO), total protein (TP), albumin (ALB), alkaline
phosphatase (ALP), aspartate transaminase (AST), alanine transaminase
(ALT), total bilirubin (TBIL), direct bilirubin (DBIL), urea,
creatinine, uric acid (UA), creatine kinase (CK), creatine kinase-MB
(CK-MB), lactic dehydrogenase (LDH), alpha-hydroxybutyric dehydrogenase
(HBDH) and hypersensitive troponin -I (HSTN-I). The details of these
clinical data characteristics are provided in the
Supplemental
Material 1. The glomerular
filtration rate (GFR) for children older than 1 and younger than 18 was
calculated using the creatinine-based “Bedside Schwartz” equation
(currently considered the best method for estimating GFR in children)
[13]. For children under 1 year old, the GFR was estimated using the
original Schwartz equation [14]. This clinical trial protocol was
approved by the Ethics Committee of Beijing Children’s Hospital
(Approval number: [2016]-Y-013-C-02). Written informed consent was
obtained from each enrolled patient or their legally authorized
guardian.