Figure1. Protocol and results of the treatment in this study .IVIG,intravenous immunoglobulin;CAL, coronary arterial lesion; MPT,methylprednisolone pulse therapy
As shown (figure1), 955 patientswith KD were treated with IVIG (2g/kg) immediatelyafter being diagnosed with KD. 875 of these patients (91.62%) were clinical responders to the initial treatment, and 26 of these patients(2.97%) showed coronary artery lesion. However, the remaining 80 patients(8.38%) were assessed as IVIG resistant,and 33 of these patients(41.25%) showed coronary artery lesion. 80 IVIG-resistant patientswere randomly divided into two groups:Group A receiving additional IVIG (n =40, 2g/kg), Group B receivingmethylprednisolone pulse therapy(MPT,n =40,methylprednisolone 15mg/kgintravenously for 3 days, without asubsequent course and taper of oral prednisone)within 36h after initial IVIG treatment.Although 5 patients developed bradycardia in thesteroid pulse group, these cases improved spontaneously.