References
1. Houghton CA. Sulforaphane: Its ”Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease. Oxid Med Cell Longev. 2019;2019:2716870.
2. Horowitz RI, Freeman PR. Three novel prevention, diagnostic, and treatment options for COVID-19 urgently necessitating controlled randomized trials. Med Hypotheses. 2020;143:109851.
3. Quirante-Moya S, Garcia-Ibanez P, Quirante-Moya F, Villano D, Moreno DA. The Role of Brassica Bioactives on Human Health: Are We Studying It the Right Way? Molecules. 2020;25(7).
4. Hindson J. Brassica vegetable metabolism by gut microbiota. Nat Rev Gastroenterol Hepatol. 2020;17(4):195.
5. Zhang J-j, Dong X, Cao Y-y, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China.n/a(n/a).
6. Azkur AK, Akdis M, Azkur D, et al. Immune response to SARS-CoV-2 and mechanisms of immunopathological changes in COVID-19.n/a(n/a).
7. Radzikowska U, Ding M, Tan G, et al. Distribution of ACE2, CD147, CD26 and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors.n/a(n/a).
8. Pfaar O, Torres MJ, Akdis CA. COVID-19: A series of important recent clinical and laboratory reports in immunology and pathogenesis of SARS-CoV-2 infection and care of allergy patients.n/a(n/a).
9. Du H, Dong X, Zhang J-j, et al. Clinical characteristics of 182 pediatric COVID-19 patients with different severities and allergic status.n/a(n/a).
10. Sokolowska M, Lukasik Z, Agache I, et al. Immunology of COVID-19: mechanisms, clinical outcome, diagnostics and perspectives – a report of the European Academy of Allergy and Clinical Immunology (EAACI).n/a(n/a).
11. Riggioni C, Comberiati P, Giovannini M, et al. A compendium answering 150 questions on COVID-19 and SARS-CoV-2.n/a(n/a).
12. Bousquet J, Anto JM, Iaccarino G, et al. Is diet partly responsible for differences in COVID-19 death rates between and within countries?Clin Transl Allergy. 2020;10:16.
13. Fonseca S, Rivas I, Romaguera D, et al. Association between consumption of fermented vegetables and COVID-19 mortality at a country level in Europe MEDRXIV/2020/147025 2020.
14. Fonseca JA. Manuscript in preparation. 2020.
15. Zabetakis I, Lordan R, Norton C, Tsoupras A. COVID-19: The Inflammation Link and the Role of Nutrition in Potential Mitigation.Nutrients. 2020;12(5).
16. Melini F, Melini V, Luziatelli F, Ficca AG, Ruzzi M. Health-Promoting Components in Fermented Foods: An Up-to-Date Systematic Review. Nutrients. 2019;11(5).
17. Senger DR, Li D, Jaminet SC, Cao S. Activation of the Nrf2 Cell Defense Pathway by Ancient Foods: Disease Prevention by Important Molecules and Microbes Lost from the Modern Western Diet. PLoS One. 2016;11(2):e0148042.
18. Finucane FM, Davenport C. Coronavirus and Obesity: Could Insulin Resistance Mediate the Severity of Covid-19 Infection? Front Public Health. 2020;8:184.
19. Guzik TJ, Cosentino F. Epigenetics and Immunometabolism in Diabetes and Aging. Antioxid Redox Signal. 2018;29(3):257-274.
20. Miedema MD, Maziarz M, Biggs ML, et al. Plasma-free fatty acids, fatty acid-binding protein 4, and mortality in older adults (from the Cardiovascular Health Study). Am J Cardiol. 2014;114(6):843-848.
21. Hurrle S, Hsu WH. The etiology of oxidative stress in insulin resistance. Biomed J. 2017;40(5):257-262.
22. Wen H, Gwathmey JK, Xie LH. Oxidative stress-mediated effects of angiotensin II in the cardiovascular system. World J Hypertens.2012;2(4):34-44.
23. Bhatt SR, Lokhandwala MF, Banday AA. Vascular oxidative stress upregulates angiotensin II type I receptors via mechanisms involving nuclear factor kappa B. Clin Exp Hypertens. 2014;36(6):367-373.
24. Dalan R, Bornstein SR, El-Armouche A, et al. The ACE-2 in COVID-19: Foe or Friend? Horm Metab Res. 2020;52(5):257-263.
25. Sarzani R, Giulietti F, Di Pentima C, Giordano P, Spannella F. Disequilibrium between the Classic Renin-Angiotensin System and Its Opposing Arm in Sars-Cov-2 Related Lung Injury. Am J Physiol Lung Cell Mol Physiol. 2020.
26. Tonelli C, Chio IIC, Tuveson DA. Transcriptional Regulation by Nrf2.Antioxid Redox Signal. 2018;29(17):1727-1745.
27. Vasileva LV, Savova MS, Amirova KM, Dinkova-Kostova AT, Georgiev MI. Obesity and NRF2-mediated cytoprotection: Where is the missing link?Pharmacol Res. 2020;156:104760.
28. Guo Z, Mo Z. Keap1-Nrf2 signaling pathway in angiogenesis and vascular diseases. J Tissue Eng Regen Med. 2020;14(6):869-883.
29. McCord JM, Hybertson BM, Cota-Gomez A, Gao B. Nrf2 Activator PB125(R) as a Potential Therapeutic Agent Against COVID-19.bioRxiv. 2020.
30. Jimenez-Osorio AS, Gonzalez-Reyes S, Pedraza-Chaverri J. Natural Nrf2 activators in diabetes. Clin Chim Acta. 2015;448:182-192.
31. Fang Y, Gao F, Liu Z. Angiotensin-converting enzyme 2 attenuates inflammatory response and oxidative stress in hyperoxic lung injury by regulating NF-kappaB and Nrf2 pathways. QJM.2019;112(12):914-924.
32. Yang L, Palliyaguru DL, Kensler TW. Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane. Semin Oncol.2016;43(1):146-153.
33. Bai Y, Wang X, Zhao S, Ma C, Cui J, Zheng Y. Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation. Oxid Med Cell Longev. 2015;2015:407580.
34. Zhou S, Wang J, Yin X, et al. Nrf2 expression and function, but not MT expression, is indispensable for sulforaphane-mediated protection against intermittent hypoxia-induced cardiomyopathy in mice. Redox Biol. 2018;19:11-21.
35. Satija A, Yu E, Willett WC, Hu FB. Understanding nutritional epidemiology and its role in policy. Adv Nutr. 2015;6(1):5-18.
36. Ozdemir C, Kucuksezer UC, Tamay Z. Is BCG vaccination effecting the spread and severity of COVID-19. Allergy. 2020.
37. Breiteneder H, Diamant Z, Eiwegger T, et al. Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care. Allergy. 2019;74(12):2293-2311.
Jean Bousquet, MD, Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Comprehensive Allergy Center, Department of Dermatology and MACVIA-France, Montpellier, France Allergy, Berlin, Germany
Josep M Anto, MD, ISGlobAL, Centre for Research in Environmental Epidemiology (CREAL), IMIM (Hospital del Mar Research Institute), Universitat Pompeu Fabra (UPF), CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
Wienczyslawa Czarlewski, MD, Medical Consulting Czarlewski, Levallois, and MASK-air, Montpellier France.
Tari Haahtela, MD, Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.
Susana C Fonseca, PhD, GreenUPorto - Sustainable Agrifood Production Research Centre, DGAOT, Faculty of Sciences, University of Porto, Campus de Vairão, Rua da Agrária, Porto, Portuga
Guido Iaccarino, MD, Federico II University, Department of Advanced Biomedical Sciences, Napoli, Italy.
Hubert Blain, MD, Pole Gérontologie, University Hospital, Montpellier University, MUSE, Montpellier.
Cezmi A Akdis, MD, Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
Torsten Zuberbier, MD, Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Comprehensive Allergy Center, Department of Dermatology, Berlin Germany
Figure 1: COVID-19 deaths per million inhabitants (May 20, 2020)