Conclusions
Estrogens, progesterone and its physiologically-active metabolite,
allopregnanolone levels increase during pregnancy and quickly drop
postpartum, which is associated with increased inflammation. These
hormones are involved in pleiotropic actions that range from improvement
of mood disorders to anti-inflammatory properties. Estrogens and
progesterone play relevant immunomodulatory functions by modulating T
cell activation and inducing immune tolerance. Allopregnanolone can also
protect from cognitive deficits. These actions may be significant in
protecting against COVID-19 and suggest that these steroids may offer a
treatment to improve COVID-19 symptoms.