Introduction
Isolated premature ventricular complexes (PVCs) are the most common arrhythmias observed in daily clinical practice in even patients without structural heart disease1. Many patients with PVCs often experience disabling symptoms and sometimes need long-term antiarrhythmic medications. In recent years, radiofrequency catheter ablation (RFCA) has proven to be a safe and successful therapy for arrhythmias including PVCs1, 2. Moreover, we previously and recently reported the clinical benefit of RFCA of PVCs from the right ventricular outflow tract (RVOT-PVCs)1, which are one of the most common types of PVCs, and from near His-bundle2, which are a comparably uncommon type of PVC. In particular, eliminating frequent RVOT-PVCs by RFCA could steadily reverse RVOT-PVC induced left ventricular (LV) dilation, which is known to be a risk factor for LV dysfunction and congestive heart failure3. Although the PVCs from near the mitral annulus (MA) (MA-PVCs) are also comparably uncommon, they also often cause a deterioration of the patients’ clinical status. Further, it is still unknown whether MA-PVCs cause LA dilation and / or dysfunction. Thus, the purpose of this study was two-fold and was 1) to examine whether frequent MA-PVCs may cause LV dilation and / or dysfunction and 2) to evaluate the effect of ablating PVCs by RFCA from a trans-interatrial septal approach on the LV dilation and clinical status in symptomatic patients with frequent MA-PVCs without structural heart disease.