INTRODUCTION
Intracardiac masses are usually detected incidentally during echocardiography or in the setting of a systematic approach to a patient’s symptoms. The most common entities are thrombi, vegetation, and to a lesser extent, cardiac tumors1; nonetheless, on the rare occasion of the presence of multiple intracardiac masses, all of them should be considered in the differential diagnosis.2, 3 Intracardiac thrombosis (ICT) is commonly detected in the presence of a predisposing factor; in some instances, however, it implies a potentially underlying serious condition, the most notable instance of which is the possibility of systemic inflammatory diseases in the presence of right heart thrombi.3, 4 Antiphospholipid syndrome (APS) is a heterogeneous autoimmune disease that is characterized by vascular thrombosis, complicated pregnancy, and elevated antiphospholipid antibodies. Although valvular disease is the most common presentation of APS, ICT may be the main clinical manifestation of this systemic inflammatory disease.5 We herein describe a young man with a diagnosis of APS who presented with fever and multiple intracardiac masses. Besides highlighting this rare presentation, we underscore the diagnostic and therapeutic value of inflammatory thrombosis.