Figure 4. Linagliptin reversed the increased expression of
acetylated lysine, perilipin-2 and NNMT in OSI-906-treated liver.
(a ) Immunoblotting for pan acetyl-lysine, Perilipin-2, and NNMT
in the liver (n = 3 per group, respectively).
(b ) Hepatic gene expressions of Cyp2b10 , Plin2and NNMT on day 7. Data represent the mean ± SEM. *P< 0.05, **P < 0.01 (n = 5 in Vehicle, Lina,
OSI-906 + Lina group, respectively, n = 4 in OSI-906 group) by ANOVA
with an additional Tukey-Kramer post-hoc test.