Figure 7. Impact of linagliptin or liraglutide on gene expressions in OSI-906-treated AML-12 cells.
The gene expressions of the indicated genes in AML-12 cells treated with 10 nM linagliptin or 100 nM liraglutide in the presence of 200 nM OSI-906 are shown. Cells were serum-starved overnight and then incubated with OSI-906 for 4 hours before the treatment with linagliptin or liraglutide. Then, the cells were incubated for 24 hours with the indicated drugs.
Data represent the mean ± SEM (n = 4 in Vehicle, OSI-906 + Linagliptin, OSI-906 + Liraglutide group, respectively, n = 5 in OSI-906 group).