AUTHOR CONTRIBUTION
T.O., J.S., and Y.Te. designed the study. T.O., K.T., T.I., S.Y., and J.S. performed the experiments, analyzed the data and wrote the manuscript. Y.I., Y.To, M.K., R.I., D.M., J.L., N.G., H.O.,R.T, Y.K., and H.H. assisted in the experiments. All authors gave final approval of the version to be published. J.S. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.