Figure 2. Linagliptin improved hepatic steatosis evoked by OSI-906.
(a ) Hematoxylin and eosin-stained sections of liver on day 7. Scale bar = 200 μm.
(b ) Ratio of liver weight to body weight on day 7 (n = 6 in Vehicle, Lina, OSI-906 + Lina group, respectively, n = 5 in OSI-906 group).
(c ) (d ) Triglyceride (TG) and glycogen content in the liver on day 7 (n = 5 per group, respectively).
(e ) Hepatic gene expressions of the indicated molecules on day 7 (n = 5 in Vehicle, Lina, OSI-906 + Lina group, respectively, n = 4 in OSI-906 group).
Data represent the mean ± SEM. *P < 0.05, **P< 0.01 by ANOVA with an additional Tukey-Kramer post-hoc test.