FUNDING
This work was supported in part by Grants-in-Aid for Scientific Research (B) 16H05329 from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan (to Y.Te.), a Grant-in-Aid for Young Scientists (B) 18K16240 from MEXT of Japan, Junior Scientist Development Grant provided by Novo Nordisk Pharma Ltd., Kanae Foundation for the Promotion of Medical Science, Suzuken Memorial Foundation, Japan Foundation for Applied Enzymology (FFDR), Ono Medical Research Foundation, Kamome Memorial Foundation of Yokohama City University, Takeda Science Foundation, the Mochida Memorial Foundation for Medical and Pharmaceutical Research, and a grant from the Japan IDDM network (to J.S.) and a Grant-in-Aid for Young Scientists (B) from MEXT of Japan, Junior Scientist Development Grant provided by Novo Nordisk Pharma, MSD Life Science Foundation, Japan Diabetes Foundation, Japan Foundatio18K16241n for Applied Enzymology (FFDR), Wakaba Grant provided by Yokohama Foundation for Advancement of Medical Science (to T.O).