Figure 1. Linagliptin improved OSI-906-induced hypertriglyceridemia in mice after 7 days of OSI-906 administration.
(a ) Experimental protocol (n = 6 in Vehicle, Lina, OSI-906 + Lina group, respectively, n = 5 in OSI-906 group).
(b ) Body weight gain during the experiment (left), on day 3 (middle), and change in body weight on day 7 (right). Data represent the mean ± SEM. *P < 0.05 (n = 6 in Vehicle, Lina, OSI-906 + Lina group, respectively, n = 5 in OSI-906 group).
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(c ) Blood glucose levels during the experiment (left) and on day 1 (right).
(d ) Serum insulin, (e ) serum triglyceride (TG), (f ) serum free fatty acid (FFA), and (g ) serum glutamic pyruvic transaminase (GPT) levels on day 7.
Data represent the mean ± SEM. *P < 0.05, **P< 0.01 (n = 6 in Vehicle, Lina, OSI-906 + Lina group, respectively, n = 5 in OSI-906 group) by ANOVA with an additional Tukey-Kramer post-hoc test.