Short communication
SARS CoV-2 adenovirus vector and RNA based vaccines potential autoimmune complications: A Reasonable Explanation for the Sudden Death Reports.
Mina T. Kelleni, MD, PhD
pharmacology Department, College of Medicine, Minia University, Egypt
mina.kelleni@mu.edu.eg; drthabetpharm@yahoo.com
Mobile: +201200382422
https://orcid.org/0000-0001-6290-6025
Key messages:
Adenovirus vector and RNA based SARS CoV-2 vaccines possess a potential risk to induce auto-immune diseases.
Nucleic acid-based vaccination is considered first of its kind to be used in humans after their approval in Russia and UK to combat COVID-19
Clinical trials involved only tens of thousands of participants and potential autoimmune complications might be revealed only post marketing.
Autoimmune myocarditis might be the reason for the cardiac arrest/sudden death reports encountered during the clinical trials and post marketing (I've updated the text after the report coming from Portugal, sent to another journal and today we read about the report of the Florida Physician who died of immune thrombocytopenia complications, I wish I might have time soonest to update also the text here).
Smokers, obese and diabetic individuals are in general more liable to develop auto-immune diseases and an individualized risk benefit ratio should be considered before vaccination.
An advice to quit smoking, lose overweight and control of blood glucose level might prove beneficial to lower the incidence of these potential autoimmune complications.
Keywords: COVID-19, SARS CoV-2, adenovirus vector vaccines, mRNA vaccines, autoimmune diseases.