Corresponding author
Daichi Inoue
Asada Ladies Nagoya Clinic, Nagoya Building 5F, Meieki 4-6-17,
Nakamura-ku, Nagoya, Aichi, Japan 450-0002
Tel: +81-052-551-2203
Fax: +81-052-551-2252
E-mail: d_inoue@ivf-asada.jp
Abstract
Premature ovulation may occur during controlled ovarian stimulation. Usually, this is noticed and treatment is canceled before ovum pick up (OPU). In this case, a 24-year-old woman naturally conceived during the stimulation and OPU was successfully performed afterwards. Despite developing severe ovarian hyperstimulation syndrome, she delivered a healthy baby.
Key words
gonadotropin-releasing hormone (GnRH) antagonist, ovarian hyperstimulation syndrome (OHSS), pregnancy, premature ovulation, premature LH surge
Key Clinical Message
In the gonadotropin-releasing hormone (GnRH) antagonist protocol, it is necessary to reinforce contraceptive guidance assuming that luteinizing hormone surge is not detected by measurement of serum level and ovulation is not suppressed by GnRH antagonist.