In the case of the pEDN for protein A (equation (2)), the first term is the direct contribution from the monomers of protein A, and the second term is a two-body correction from the dimers of protein A. The third term is a two-body correction from the dimers between proteins A and B, which is halved and added to the pEDN of protein A. For protein B, the pEDN is similarly defined (equation (3)). Notably, the total EDN of the complex (equation (1)) is given by a simple sum of the pEDNs for proteins A (equation (2)) and B (equation (3)):