PK interactions PK interactions PK interactions PK interactions PK interactions PK interactions PD interactions PD interactions PD interactions
HCQ/CQ
Azithromycin
Lopinavir/r
Tocilizumab Interferon-β
Remdesivir
Favipiravir
HCQ/CQ Azithromycin Favipiravir Lopinavir/r
Lopinavir/r
Lopinavir/r Tocilizumab Remdesivir
cytochromes involved in interaction
cytochromes involved in interaction
cytochromes involved in interaction
S3A4
Ih3A4 S3A4 Ih3A4 Ih2D6 S3A4
Ih3A4
Id1A2 (S3A4)
Ih 2C8
QT
Nephro tox
Liver tox
EGFR Erlotinib S3A4 / S1A2 S3A4 / S1A2 S3A4 / S1A2
Osimertinib S3A4 S3A4 S3A4
Cetuximab
HER2 Trastuzumab
Pertuzumab
Lapatinib S3A4 / Ih3A4 / S2C8 S3A4 / Ih3A4 / S2C8 S3A4 / Ih3A4 / S2C8
VEGF Bevacizumab
Ramucirumab
BRAF Vemurafenib S3A4 / Id3A4 S3A4 / Id3A4 S3A4 / Id3A4
Dabrafenib S3A4 / Id3A4 S2C8 S3A4 / Id3A4 S2C8 S3A4 / Id3A4 S2C8
ALK Crizotinib S3A4 / Ih3A4 S3A4 / Ih3A4 S3A4 / Ih3A4
Alectinib
Ceritinib S3A4 / Ih3A4 S3A4 / Ih3A4 S3A4 / Ih3A4
FGFR Erdafitinib S3A4 S3A4 S3A4
Endocrine therapies Tamoxifen* S3A4 / Id3A4 / S2D6 S3A4 / Id3A4 / S2D6 S3A4 / Id3A4 / S2D6
Fulvestrant
Anastrozole
Letrozole
Exemestane
Abiraterone (S3A4) / Ih3A4 (S3A4) / Ih3A4 (S3A4) / Ih3A4
Enzalutamide (S3A4) / Id3A4 S2C8 (S3A4) / Id3A4 S2C8 (S3A4) / Id3A4 S2C8
GnRH analogs
Immuno-therapy antiPD1/PDL1