Pooled rates of overall death, spontaneous myocardial infarction and target vessel revascularisation [four double-arm studies (two randomised and two observational) and two single-arm studies]
By carrying out a pooled analysis in the data of all six studies (two randomised12,13, two double-arm observational14,15 and two single-armed16,17) we noted that FFR-guided CABG was associated with lower overall death rates as compared to CAG-guided CABG 6.1% [95% CI: 3.2% – 9.7%] (Figure 6A) vs 7.1% [95% CI: 2.8% – 13.1%] (Figure 6B). However, the rate of overall death in the CAG-guided CABG had a considerable risk of heterogeneity (I2 = 82.52%, P <0.001). FFR-guided CABG also showed lower rates of spontaneous MI as compared to CAG-guided CABG 2.5% [95% CI: 0.9% – 4.9%] (Figure 7A), vs 5.0% [95% CI: 2.2% – 8.8%] (Figure 7B). FFR-guided CABG showed greater rates of target vessel revascularisation 6.8% [95% CI: 3.5% – 11.0%] (Figure 8A), vs 4.9% [95% CI: 2.6% – 7.8%] (Figure 8B).