Total number of grafts occluded (double-arm randomised and observational studies)
Comparing the results of 2 randomised control studies12,13 with a total of 493 vessels evaluated by angiographic follow up, we noted no significant difference in the rates of graft occlusion between the two groups (RR: 1.05, 95% CI: 0.72 to 1.54, p = 0.79) (Figure 4E). Only one observational study15 reported the findings of angiographic evaluation of the grafts. With a total of 234 grafts evaluated in this study, there was significantly lower overall graft occlusion rates in the FFR-guided CABG as compared to CAG-guided CABG. (RR: 0.24, 95% CI: 0.08 to 0.76, p = 0.01) (Figure 4E). However, due to only one study reporting a significant difference, the effect was not large enough to demonstrate a significant result overall, and in the analysis of all 3 studies, with a total of 727 patients, we observed no difference in the rates of graft occlusion between the FFR-guided and CAG-guided groups (RR: 0.81, 95% CI: 0.57 to 1.15, p=0.24) (Figure 4E).