Reference
1. Andrade J, Khairy P, Dobrev D, Nattel S (2014) The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms. Circulation research 114(9):1453-1468.
2. Simantirakis EN, Papakonstantinou PE, Kanoupakis E, et al. (2018) Recurrence rate of atrial fibrillation after the first clinical episode: A prospective evaluation using continuous cardiac rhythm monitoring. Clin Cardiol 41(5):594-600.
3. Dorian P, Paquette M, Newman D, et al. (2002) Quality of life improves with treatment in the Canadian Trial of Atrial Fibrillation. American heart journal 143(6):984-990.
4. Mark DB, Anstrom KJ, Sheng S, et al. (2019) Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial. Jama 321(13):1275-1285.
5. January CT, Wann LS, Alpert JS, et al. (2014) 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. Circulation 130(23):2071-2104.
6. Ghia KK, Chugh A, Good E, et al. (2009) A nationwide survey on the prevalence of atrioesophageal fistula after left atrial radiofrequency catheter ablation. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 24(1):33-36.
7. Garg L, Garg J, Gupta N, et al. (2016) Gastrointestinal complications associated with catheter ablation for atrial fibrillation. International journal of cardiology 224:424-430.
8. Wilber DJ, Pappone C, Neuzil P, et al. (2010) Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation: a randomized controlled trial. Jama 303(4):333-340.
9. Packer DL, Kowal RC, Wheelan KR, et al. (2013) Cryoballoon ablation of pulmonary veins for paroxysmal atrial fibrillation: first results of the North American Arctic Front (STOP AF) pivotal trial. J Am Coll Cardiol 61(16):1713-1723.
10. Morillo CA, Verma A, Connolly SJ, et al. (2014) Radiofrequency ablation vs antiarrhythmic drugs as first-line treatment of paroxysmal atrial fibrillation (RAAFT-2): a randomized trial. JAMA 311(7):692-700.
11. Cosedis Nielsen J, Johannessen A, Raatikainen P, et al. (2012) Radiofrequency ablation as initial therapy in paroxysmal atrial fibrillation. N Engl J Med 367(17):1587-1595.
12. Wazni OM, Marrouche NF, Martin DO, et al. (2005) Radiofrequency ablation vs antiarrhythmic drugs as first-line treatment of symptomatic atrial fibrillation: a randomized trial. JAMA 293(21):2634-2640.
13. Hakalahti A, Biancari F, Nielsen JC, Raatikainen MJ (2015) Radiofrequency ablation vs. antiarrhythmic drug therapy as first line treatment of symptomatic atrial fibrillation: systematic review and meta-analysis. Europace 17(3):370-378.
14. Andrade JG, Wells GA, Deyell MW, et al. (2020) Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation. N Engl J Med;10.1056/NEJMoa2029980.
15. Wazni OM, Dandamudi G, Sood N, et al. (2020) Cryoballoon Ablation as Initial Therapy for Atrial Fibrillation. N Engl J Med;10.1056/NEJMoa2029554.
16. Tierney JF, Stewart LA, Ghersi D, Burdett S, Sydes MR (2007) Practical methods for incorporating summary time-to-event data into meta-analysis. Trials 8:16.
17. Higgins JP, Altman DG, Gotzsche PC, et al. (2011) The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 343:d5928.
18. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177-188.
19. Sterne JA, Egger M (2001) Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol 54(10):1046-1055.
20. Simmonds M (2015) Quantifying the risk of error when interpreting funnel plots. Systematic reviews 4:24-24.
21. Debray TPA, Moons KGM, Riley RD (2018) Detecting small-study effects and funnel plot asymmetry in meta-analysis of survival data: A comparison of new and existing tests. Research synthesis methods 9(1):41-50.
22. Kuck KH, Brugada J, Furnkranz A, et al. (2016) Cryoballoon or Radiofrequency Ablation for Paroxysmal Atrial Fibrillation. N Engl J Med 374(23):2235-2245.
Table 1: Study characteristics of included randomized controlled trials
Table 2: Basic characteristics of study participants
Table 3: Cochrane Collaboration tool to assess risk of bias for randomized controlled trials
Table 4: Summary of adverse events
Fig. 1: PRISMA flow diagram.
Fig. 2: Forest plot of the included studies comparing arrhythmia-free survival between ablation group and antiarrhythmic medication group; 2A: Cryoablation, 2B: Radiofrequency ablation
Supplementary material 1: Search term