6. Conclusions
In this updated systematic review and meta-analysis of RCTs, that now includes RCTs that specifically use cryoballoon ablation only, we found that catheter ablation is more effective than AADs as an initial therapy for pAF in reducing AT recurrences over 1-2 years following the treatment initiation. These results are the same with use of both cryoablation and radiofrequency ablation approaches. The adverse event rates are low with contemporary use of AADs and with evolved catheter ablation tools and there were no differences in any adverse events between the two groups.