PK and BE Analysis
PK parameters such as AUC0-t, AUC0-∞,
Cmax , the elimination
half-life(T1/2), and time to achieve the
Cmax (Tmax ) were determined. The
pharmacokinetic parameters of rasagiline were calculated with WinNonlin
Version 6.4 by non-compartment model. The AUC was calculated by the
linear trapezoidal linear interpolation method. The experimental results
were mainly analyzed by descriptive statistics using SAS (SAS Institute,
USA, version 9.4). The main pharmacokinetic indexes after logarithmic
transformation were analyzed by a mixed effect model. The level of
significance was set at P <0.05.