Associations of fasting complement concentrations and metabolic parameters
The associations between circulating complement levels and a range of anthropometric and metabolic risk measures are shown in table S2. Across the whole cohort (PCOS and controls), triglycerides, and to a lesser extent LDL cholesterol, correlated strongly with early complement pathway components and activation products but weakly with terminal components and activation products (C5, C5a(desArg) and TCC). Both early and late complement pathway components were significantly associated with both visceral and subcutaneous fat area. HOMA-IR was most strongly associated with C3, factor H and properdin.