References
1. Khor, B., A. Gardet, and R. Xavier, Genetics and pathogenesis
of inflammatory bowel disease. Nature, 2011. 474: p. 307-317.
2. Ahuja, V. and R.K. Tandon, Inflammatory bowel disease in the
Asia–Pacific area: A comparison with developed countries and regional
differences. Journal of Digestive Diseases, 2010. 11.
3. Lee, Y.M., K. Fock, S.J. See, T.M. Ng, and E.K. Teo, Racial
difference in the prevalence of ulcerative colitis and Crohn’s disease
in Singapore. Journal of Gastroenterology & Hepatology, 2000. 15(6):
p. 622-625.
4. Zheng, J., Ju, S.Z. Xia, H. Zhao, H.S. Xiao, and R.G. Zhi,Prevalence and incidence rates of Crohn’s disease in mainland
China: A meta-analysis of 55 years of research. Journal of Digestive
Diseases, 2010. 11(3): p. 161-166.
5. Wilson, M.J., M. Torkar, A. Haude, S. Milne, T. Jones, D. Sheer, S.
Beck, and J. Trowsdale, Plasticity in the organization and
sequences of human KIR/ILT gene families. Proceedings of the National
Academy of Sciences of the United States of America, 2000. 97(9): p.
4778-4783.
6. Armin, V., W. Hagen, L. Katja, and Z. Andreas, Genesis of the
ILT/LIR/MIR clusters within the human leukocyte receptor complex .Immunological Reviews, 2002. 181(1): p. 39-51.
7. Barten, R., M. Torkar, A. Haude, J. Trowsdale, and M.J. Wilson,Divergent and convergent evolution of NK-cell receptors. Trends
in Immunology, 2001. 22(1): p. 52-57.
8. Torkar, M., A. Haude, S. Milne, S. Beck, and M.J. Wilson,Arrangement of the ILT gene cluster: A common null allele of the
ILT6 gene results from a 6.7-Kbp deletion. European Journal of
Immunology, 2001. 30(12): p. 3655-3662.
9. Torkar, M., Z. Norgate, M. Colonna, J. Trowsdale, and M.J. Wilson,Isotypic variation of novel immunoglobulin-like transcript/killer
cell inhibitory receptor loci in the leukocyte receptor complex.European Journal of Immunology, 1998. 28(12): p. 3959-3967.
10. Kabalak, G., S. Koch, B. Dobberstein, Y.H. The, T. Matthias, S.
Schnarr, R.E. Schmidt, and T. Witte, Immunoglobulin-like
Transcripts as Risk Genes for Autoimmunity. Ann N Y Acad Sci, 2007.
1110(Autoimmunity Part B Novel Applications of Basic Research): p.
10-14.
11. Kabalak, G., S.B. Dobberstein, T. Matthias, S. Reuter, and T. Witte,Association of immunoglobulin-like transcript 6 deficiency with
Sjögren’s syndrome. Arthritis Rheum, 2009. 60(10): p. 2923-2925.
12. Ordó?Ez, D., A.J. Sánchez, J.E. Martínez-Rodríguez, E. Cisneros, E.
Ramil, N. Romo, M. Moraru, E. Munteis, M. López-Botet, et al.,Multiple sclerosis associates with LILRA3 deletion in Spanish
patients. Genes & Immunity, 2009. 10(6): p. 579-585.
13. Du, Y., Y. Cui, X. Liu, F. Hu, and Z. Li, Contribution of
Functional LILRA3, but Not Nonfunctional LILRA3, to Sex Bias in
Susceptibility and Severity of Anti-Citrullinated Protein
Antibody-Positive Rheumatoid Arthritis. Arthritis & Rheumatology,
2014. 66(4): p. 822-830.
14. Koch, S., R. Goedde, V. Nigmatova, J.T. Epplen, N. Müller, J. de
Seze, P. Vermersch, T. Momot, R.E. Schmidt, et al., Association of
multiple sclerosis with ILT6 deficiency. Genes & Immunity, 2005. 6(5):
p. 445-447.
15. Yang, J., W. Li, G. Xin, T. Sha, T. Lu, N. Rong, C. Zhuo, K. Jian,
Z. Siqun L, et al., LILRA3 Is Associated with Benign Prostatic
Hyperplasia Risk in a Chinese Population. International Journal of
Molecular Sciences, 2013. 14(5): p. 8832-8840.
16. Xu, J., Z. Mo, D. Ye, M. Wang, F. Liu, G. Jin, C. Xu, X. Wang, Q.
Shao, et al., Genome-wide association study in Chinese men
identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4.Nature Genetics, 2012. 44(11): p. 1231-1235.
17. Tedla, N., H. An, L. Borges, U. Vollmer-Conna, K. Bryant, C. Geczy,
and H.P. McNeil, Expression of activating and inhibitory leukocyte
immunoglobulin-like receptors in rheumatoid synovium: correlations to
disease activity. Tissue Antigens, 2011. 77(4): p. 305-316.
18. Du, Y., Y. Su, J. He, Y. Yang, and Z. Li, Impact of the
leucocyte immunoglobulin-like receptor A3 (LILRA3) on susceptibility and
subphenotypes of systemic lupus erythematosus and Sjogren’s syndrome.Annals of the Rheumatic Diseases, 2014. 74(11): p. 2070-2075.
19. An, H., L. Chai, G.G. J., V.-C. Ute, R. William, B. Katherine, T.
Nicodemus, and N. Serge, Serum Leukocyte Immunoglobulin-Like
Receptor A3 (LILRA3) Is Increased in Patients with Multiple Sclerosis
and Is a Strong Independent Indicator of Disease Severity; 6.7kbp LILRA3
Gene Deletion Is Not Associated with Diseases Susceptibility. Plos One,
2016. 11(2): p. e0149200-.
20. An, H., V. Chandra, B. Piraino, L. Borges, C. Geczy, H.P. Mcneil, K.
Bryant, and N. Tedla, Soluble LILRA3, a potential natural
antiinflammatory protein, is increased in patients with rheumatoid
arthritis and is tightly regulated by interleukin 10, tumor necrosis
factor-alpha, and interferon-gamma. Journal of Rheumatology, 2010.
37(8): p. 1596-1606.
21. Zhi, L.H., R. Sandra, T. Michael, D. Nadine, P. Dietrich, K. Gamze,
S. Renata, S.R. E., M. Torsten, et al., Association of the LILRA3
Deletion with B-NHL and Functional Characterization of the
Immunostimulatory Molecule. Plos One, 2013. 8(12): p. e81360.
22. An, H., M. Brettle, T. Lee, B. Heng, C.K. Lim, G.J. Guillemin, M.S.
Lord, E. Klotzsch, C.L. Geczy, et al., Soluble LILRA3 promotes
neurite outgrowth and synapses formation through high affinity
interaction with Nogo 66. Journal of Cell Science, 2016: p. jcs.182006.
23. Lee, T.H.Y., A. Mitchell, S. Liu Lau, H. An, P. Rajeaskariah, V.
Wasinger, M. Raftery, K. Bryant, and N. Tedla, Glycosylation in a
Mammalian Expression System Is Critical for the Production of
Functionally Active Leukocyte Immunoglobulin-like Receptor A3 Protein.Journal of Biological Chemistry, 2013. 288(46): p. 32873-32885.
24. Brown, D., J. Trowsdale, and R. Allen, The LILR family:
modulators of innate and adaptive immune pathways in health and
disease. Tissue Antigens, 2004. 64: p. 215-225.
25. Kane, B.A., K.J. Bryant, H.P. McNeil, and N.T. Tedla,Termination of Immune Activation: An Essential Component of
Healthy Host Immune Responses. Journal of Innate Immunity, 2014. 6(6):
p. 727-738.
26. Geissmann, F., M.G. Manz, S. Jung, M.H. Sieweke, M. Merad, and K.
Ley, Development of Monocytes, Macrophages, and Dendritic Cells.2010. 327(5966): p. 656-661.
27. Auffray, C., M.H. Sieweke, and F. Geissmann, Blood Monocytes:
Development, Heterogeneity, and Relationship with Dendritic Cells.Annual Review of Immunology, 2009. 27(1): p. 669-692.
28. Liu, C., X. Xu, and Y. Zhou, Association between EGFR
polymorphisms and the risk of lung cancer. International Journal of
Clinical & Experimental Pathology, 2015. 8(11): p. 15245-15249.
29. Liang, J., T. Zhao, J. Yang, W. Li, F. Zhang, S. Zhang, Z. Huang, R.
Lin, and X. Zhang, MMP-9 gene polymorphisms (rs3918242, rs3918254
and rs4810482) and the risk of psoriasis vulgaris: No evidence for
associations in a Chinese Han population. Immunology Letters, 2015.
168(2): p. 343-348.
30. Hirayasu, K., J. Ohashi, H. Tanaka, K. Kashiwase, A. Ogawa, M.
Takanashi, M. Satake, G.J. Jia, N.-O. Chimge, et al., Evidence for
Natural Selection on Leukocyte Immunoglobulin-like Receptors for HLA
Class I in Northeast Asians. The American Journal of Human Genetics,
2008. 82(5): p. 1075-1083.
31. Murphy, J.E., P.R. Tedbury, S. Homer-Vanniasinkam, J.H. Walker, and
S. Ponnambalam, Biochemistry and cell biology of mammalian
scavenger receptors. Atherosclerosis, 2005. 182(1): p. 1-15.
32. Martinez‐Pomares, L., The mannose receptor. Journal of
Leukocyte Biology, 2012. 92.
33. Jones, D.C.D., V.V. Kosmoliaptsis, R.R. Apps, N.N. Lapaque, I.I.
Smith, A.A. Kono, C.C. Chang, L.H.L. Boyle, C.J.C. Taylor, et al.,HLA class I allelic sequence and conformation regulate leukocyte
Ig-like receptor binding. Journal of immunology, 2011. 186(5): p. 2990.
34. Shiroishi, M., K. Tsumoto, K. Amano, Y. Shirakihara, M. Colonna,
V.M. Braud, D.S.J. Allan, A. Makadzange, S. Rowland-Jones, et al.,Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4
compete with CD8 for MHC class I binding and bind preferentially to
HLA-G. Proceedings of the National Academy of Sciences of the United
States of America, 2003. 100(15): p. 8856-8861.
35. Jones, D.C., A. Roghanian, D.P. Brown, C. Chang, R.L. Allen, J.
Trowsdale, and N.T. Young, Alternative mRNA splicing creates
transcripts encoding soluble proteins from most LILR genes. European
Journal of Immunology, 2009. 39(11): p. 3195-3206.
36. Gerhardt, T. and K. Ley, Monocyte trafficking across the
vessel wall. Cardiovascular Research, 2015. 107(3): p. 321-30.
37. SAVILL, J., Thrombospondin cooperates with CD36 and the
vitronectin receptor in macrophage recognition of neutrophils undergoing
apoptosis. Journal of Clinical Investigation, 1992. 90.
38. Febbraio, M., D.P. Hajjar, and R.L. Silverstein, CD36: a class
B scavenger receptor involved in angiogenesis, atherosclerosis,
inflammation, and lipid metabolism. Journal of Clinical Investigation,
2001. 108(6): p. 785-791.
39. Greenwalt, D.E., R.H. Lipsky, C.F. Ockenhouse, H. Ikeda, and G.A.
Jamieson, Membrane Glycoprotein CD36: A Review of Its Roles in
Adherence, Signal Transduction, and Transfusion Medicine. Blood, 1992.
80(5): p. 1105-1115.
40. Furukawa-Hibi, Y., Y. Kobayashi, C. Chen, and N. Motoyama,FOXO Transcription Factors in Cell-Cycle Regulation and the
Response to Oxidative Stress. Antioxid Redox Signal, 2005. 7(5-6): p.
752-760.
41. Huang, H. and D.J. Tindall, FOXO factors: a matter of life and
death. Future Oncology, 2006. 2(1): p. 83-89.
42. Burgering, B.M.T. and G.J.P.L. Kops, Cell cycle and death
control: long live Forkheads. Trends in Biochemical Sciences, 2002.
27(7): p. 352-360.
43. Woods, Y.L. and G. Rena, Effect of multiple phosphorylation
events on the transcription factors FKHR, FKHRL1 and AFX. Biochemical
Society transactions, 2002. 30(4): p. 391.
44. G J, K., Direct control of the Forkhead transcription factor
AFX by protein kinase B. Nature, 1999. 6728(398).
45. Yang, J., ERK promotes tumorigenesis by inhibiting FOXO3a via
MDM2-mediated degradation. Nature cell biology, 2008. 2(10).
46. M H, C., Regulation of cell death protease caspase-9 by
phosphorylation. Science (New York, N.Y.), 1998. 5392(282).
47. Zhang, X., N. Tang, T.J. Hadden, and A.K. Rishi, Akt, FoxO and
regulation of apoptosis. Biochimica et Biophysica Acta (BBA) -
Molecular Cell Research, 2011. 1813(11): p. 1978-1986.
48. Brunet, A., A. Bonni, M.J. Zigmond, M.Z. Lin, P. Juo, L.S. Hu, M.J.
Anderson, K.C. Arden, J. Blenis, et al., Akt Promotes Cell
Survival by Phosphorylating and Inhibiting a Forkhead Transcription
Factor. Cell, 1999. 96(6): p. 857-868.