Statistical analysis
All analyses were performed using SPSS Version 17.0 and GraphPad Prism
software version 5.0. Among the healthy controls, the distributions of
the 6.7-kb deletion genotype, rs103294 and rs410852 were in
Hardy-Weinberg Equilibrium (HWE) (p=0.55, p=0.31, p=0.55 respectively).
The χ2 test was used to analyze the frequencies of alleles and genotypes
between the cases and controls and the differences between the
sub-phenotypes of the patient groups with the controls. Odds ratios
(ORs) are provided with 95% confidence interval (CI) to estimate the
relative risk of developing CD and UC. Differences in LILRA3 mRNA and
protein expression between the patient groups and controls were analyzed
using one-way analysis of variance (ANOVA). Differences between the U937
cells harboring the null vector and overexpression plasmid were analyzed
using an unpaired t-test. A p value less than 0.05 was considered to be
statistically significant. Data are presented as mean ± SD from three
independent experiments and representative data are shown.