What next?
As shown in the table, published data to date do not support ICANS
modulation as an alternative to PV isolation. This is especially as
ablation technologies have made the latter a streamlined, safe procedure
with unequivocal objective end-points and excellent clinical results.
Whether ICANS modulation would have a role in carefully selected
subgroups, such as those with AF recurrence in spite of documented
isolated PVs, remains to be proven. As of now, we believe that when it
comes to the ablating the autonomic nervous system in AF, it may be
preferable to take flight rather than to fight.