Comparison of SCE Incidence between Oral Anticoagulants
Figure 2 showed the incidence of SCEs in each anticoagulant. Warfarin and apixaban had higher incidence of SCEs than the other drugs although the difference did not reach statistical significance.
We assumed that there may be differences in clinical characteristics between patients with different oral anticoagulants, which may also affect the incidence of SCEs. We compared the patient-dependent factors associated with SCEs identified by univariate/multivariate analyses among the five anticoagulants. Age, the prevalence of persistent AF, CHADS2/CHA2DS2-VASc scores, and LAD were significantly different among the anticoagulants (Table 3). Apixaban and warfarin were prescribed in the more elderly patients with the higher CHADS2/CHA2DS2-VASc scores. On the other hand, edoxaban tended to be prescribed in those with the lower risks in the patient’s factors, which may also contribute to the incidence of SCE (Table 3).