Comparison of Intra-procedural ACT Kinetics between Oral
Anticoagulants
We compared the intra-procedural ACT kinetics between oral
anticoagulants (Figure 1). Dabigatran had the highest baseline ACT value
among all the agents (175±32 sec). Edoxaban (155±20 sec) showed the
lower baseline ACT value than dabigatran but had the highest value among
factor Xa inhibitors. The baseline ACT values were statistically
comparable among rivaroxaban (143±18 sec), apixaban (136±25 sec), and
warfarin (145±21 sec, Figure 1A).
Rivaroxaban (41±25 sec) and apixaban (45±28 sec) showed the
significantly longer time to reach the optimal ACT than edoxaban (29±22
sec) and warfarin (27±16 sec). Dabigatran (35±25 sec) also showed the
longer time than edoxaban and warfarin but the difference did not reach
statistical significance (Figure 1B). These suggest that the
intra-procedural ACT kinetics varies among oral anticoagulants, which
potentially affects the incidence of SCEs in each anticoagulant.