Comparison of SCE Incidence between Oral Anticoagulants
Figure 2 showed the incidence of SCEs in each anticoagulant. Warfarin
and apixaban had higher incidence of SCEs than the other drugs although
the difference did not reach statistical significance.
We assumed that there may be differences in clinical characteristics
between patients with different oral anticoagulants, which may also
affect the incidence of SCEs. We compared the patient-dependent factors
associated with SCEs identified by univariate/multivariate analyses
among the five anticoagulants. Age, the prevalence of persistent AF,
CHADS2/CHA2DS2-VASc
scores, and LAD were significantly different among the anticoagulants
(Table 3). Apixaban and warfarin were prescribed in the more elderly
patients with the higher
CHADS2/CHA2DS2-VASc
scores. On the other hand, edoxaban tended to be prescribed in those
with the lower risks in the patient’s factors, which may also contribute
to the incidence of SCE (Table 3).