Comparison of Intra-procedural ACT Kinetics between Oral Anticoagulants
We compared the intra-procedural ACT kinetics between oral anticoagulants (Figure 1). Dabigatran had the highest baseline ACT value among all the agents (175±32 sec). Edoxaban (155±20 sec) showed the lower baseline ACT value than dabigatran but had the highest value among factor Xa inhibitors. The baseline ACT values were statistically comparable among rivaroxaban (143±18 sec), apixaban (136±25 sec), and warfarin (145±21 sec, Figure 1A).
Rivaroxaban (41±25 sec) and apixaban (45±28 sec) showed the significantly longer time to reach the optimal ACT than edoxaban (29±22 sec) and warfarin (27±16 sec). Dabigatran (35±25 sec) also showed the longer time than edoxaban and warfarin but the difference did not reach statistical significance (Figure 1B). These suggest that the intra-procedural ACT kinetics varies among oral anticoagulants, which potentially affects the incidence of SCEs in each anticoagulant.