Sequence network
A threshold of 60% similarity was used to construct protein sequence
networks for LED superfamilies 11 and 13 whose members originated from
Proteobacteria only (Figure 2 ). Two disconnected sequence
networks emerged: a network of 127 representative sequences of
superfamily 11, which contains the GX-type PURases PueA andPueB from Pseudomonas chlororaphis , and a network of
fifteen representative sequences of superfamily 13, which contains the
GGGX-type the PURase PudA from Delftia acidovorans . In both
superfamilies 11 and 13, the sequences originated mainly from
Gammaproteobacteria, with the genus Pseudomonas being most
frequently annotated in superfamily 11.