Outcomes
There are currently no validated core outcome sets for twin pregnancy research, thus outcomes were based on: existing literature, discussion with representatives from the Multiple Births Foundation and the Twins Trust, and limitations noted from systematic reviews5, 7.
  1. Incidence of sIUFD after 14 weeks gestation in MC twin pregnancies.
  2. Complications associated with sIUFD: rates of sIUFD associated with antenatal complications (TTTS, sIUGR and congenital/structural anomalies), management of antenatal complications, rate of spontaneous sIUFDs
  3. Surviving co-twin outcomes: perinatal mortality (miscarriage defined as fetal death <24 weeks, and stillbirth fetal death >24 weeks), antenatal CNS imaging, gestation at delivery (if preterm <37 weeks, <34 weeks, <28 weeks, iatrogenic or spontaneous), role of induction, mode of delivery and reason if not normal vaginal delivery, post-mortem findings.
  4. Neonatal outcomes: neonatal death defined as at least until discharge, neonatal intensive care unit admission and reason, postnatal CNS imaging, abnormal neurological signs in the neonatal period.
  5. Maternal outcomes: major maternal morbidity, as reported by UKOSS studies17.