Molecular data
Molecular changes produced by genotype and AMPH exposure alone as well as by their combination were analyzed using a two-way ANOVA, with the factors genotype and type of AMPH access as independent variables. When dictated by relevant interaction terms, Tukey’s multiple comparisons test was used to characterize differences among individual groups of rats. To enable visual comparisons across genotypes with different degrees of expression of glutamatergic molecular determinants, values are presented as percentage of the AMPH -naïve SERT+/+control rats that were not exposed to either AMPH ShA or LgA. Subjects were eliminated from the final dataset if their data deviated from the mean by 2 SDs. Prism 6.0 (GraphPad) was used to analyze all the data. Data are shown as mean ± S.E.M and as % of baseline to control for unwanted sources of variation. Significance for all tests was assumed atp < 0.05.