Discussion
We found that SERT-/- rats displayed increased AMPH intake under LgA, but not ShA conditions. Furthermore, the psychomotor response to AMPH was significantly higher in SERT-/-rats. Finally, we found that, after 24 hours of withdrawal from AMPH self-administration, the glutamatergic synapse was affected differently in SERT-/- versus SERT+/+ rats, in a way that heavily relies on the subregion of the NAc (shell or core) and the type of AMPH access (ShA or LgA).