Discussion
We found that SERT-/- rats displayed increased AMPH
intake under LgA, but not ShA conditions. Furthermore, the psychomotor
response to AMPH was significantly higher in SERT-/-rats. Finally, we found that, after 24 hours of withdrawal from AMPH
self-administration, the glutamatergic synapse was affected differently
in SERT-/- versus SERT+/+ rats, in a
way that heavily relies on the subregion of the NAc (shell or core) and
the type of AMPH access (ShA or LgA).