Figure 5. Boxplots for 100 values of \(\text{SS}D_{\theta}\) for Case II, when designing three sequential A-optimal experiment one at a time using LO-LO, Bayes-LO, LO-Bayes, and Bayes-Bayes approaches
Cases I, II and III were also repeated using the extended 14 parameter model that arises (due to activation energies and reaction enthalpy) when the temperature is included as an additional decision variable. The same trends were observed as for the 7 parameters model, indicating that the Bayes-LO is the best of the four approaches studied. Details are provided in the Supplementary Information.