Objective: To review studies published with pregnant women infected with
SARS-CoV-2 and analyze the evolution of them and also of the newborn in
order to learn about this pathology in pregnant women. Search strategy:
Systematic review in the PUBMED and GOOGLE Scholar databases until March
30, 2020. This research was extended to the references of such articles.
Selection criteria: Observational studies that examined maternal and
perinatal outcomes of pregnant women with SARS-CoV-2 are published. Data
collection and analysis: Data about study characteristics, maternal y
perinatal outcomes variable extracted. Main results: We found 14
publications regarding a total of 83 pregnant women with SARS-CoV-2 and
results of 84 newborns. The average gestational age was 37 weeks. The
most common symptom was fever, and 30% of the pregnant women had
lymphopenia on admission to hospital. Cesarean section was performed in
89% of the patients; 70% of them were indicated by SARS-CoV-2. The
most common obstetric complication was premature rupture of membranes in
9.6% of them. The need for ventilation support was low. The use of
antivirals, corticosteroids, and drugs for the pathology management was
scarce, except for antibiotics. Preterm birth was 25%, perinatal
mortality was low, and there was no maternal death. There was no
evidence of vertical transmission. Conclusion: Maternal and perinatal
morbidity-mortality is lower than in other known respiratory diseases.
Currently, it appears to be no benefit from antivirals and other drugs,
beyond the general support of the disease, and vertical transmission of
the virus has not been demonstrated.