2.1 Compound-network analysis
Systems biology suggests that complex diseases may not be effectively
treated with the intervention of a single node. Therefore, finding
protein pathways and analyzing multiple proteins is an effective method.
Protein-Protein interactions (PPI) obtained from STRING database (STRING
v10.5, http://string-db.org/)19 were used to find
proteins associated with NLRP3 and Parkinson’s disease. The correlation
between related proteins, NLRP3 protein and Parkinson’s disease was
scored through a certain scoring function. The top ten proteins and
their interactions are shown in Figure 2. Diagrams Figure 3 are
constructed by analyzing the interaction relationship between NLRP3,
TP53, CASP1, HSP90AB1 which are the four related proteins and molecular
in the TCM Database @Taiwan (http://tcm.cmu.edu.tw).This chart can be
used to further analyze potential targets for Parkinson’s disease and
multi-target drugs for Parkinson’s disease.