Atherosclerosis is a serious disease that starts with a local lesion in
the vessels and progressesto a heart attack. The recent increase in
heart attack disease and the increase i n deaths related to it makes it
important to discover drug candidate ligands to be detected against the
receptors determined in this disease. In this study, chemical
calculation method was used to determine the interaction with
Atherosclerosis receptors determined by literature studies and the bonds
to be formed at the molecular level and the inhibition mechanism.The
foods, spices and active ingredients in various medicinal plants that we
consume as daily food supplements were identified as ligands at the end
of the research conducted with the literature review, and the inhibition
effects on the receptors that suppress the distribution of cholesterol,
which is one of the biggest causes of atherosclerosis, to the cells
through the blood were determined by comparing the currently used
reference drugs. The data obtained from here is important in terms of
determining drug candidate active substances in experimental and
clinical studies to be conducted on atherosclerosis, preventing time and
substance loss and giving direction.