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\begin{document}

\title{A research on the determination of effective natural compounds for
atherosclerosi}



\author[1]{Faik Gökalp}%
\affil[1]{Kirikkale University}%


\vspace{-1em}



  
  \date{May 27, 2024}


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\begin{abstract}
Background and Purpose Atherosclerosis is a serious disease that starts
with a local lesion in the vessels and progressesto a heart attack. The
recent increase in heart attack disease and the increase i n deaths
related to it makes it important to discover drug candidate ligands to
be detected against the receptors determined in this disease. Methods
and Results In this study, chemical calculation method was used to
determine the interaction with Atherosclerosis receptors determined by
literature studies and the bonds to be formed at the molecular level and
the inhibition mechanism.The foods, spices and active ingredients in
various medicinal plants that we consume as daily food supplements were
identified as ligands at the end of the research conducted with the
literature review, and the inhibition effects on the receptors that
suppress the distribution of cholesterol, one of the biggest causes of
atherosclerosis, to the cells through the blood were determined by
comparing the currently used reference drugs. The data obtained from
here is important in terms of determining drug candidate active
substances in experimental and clinical studies to be conducted on
atherosclerosis, preventing time and substance loss and giving
direction.%
\end{abstract}%



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