Abstract :
Background and Purpose
Antisense oligonucleotides (ASOs) based technology is considered a
potential strategy against antibiotic-resistant bacteria; however, a
major obstacle to the application of ASOs is how to deliver them into
bacteria effectively. DNA tetrahedra (Td) is an emerging carrier for
delivering ASOs into eukaryotes.
However, there is limited information about Td used for bacteria. In
this research, we investigated the uptake features of Td and
the impact of linkage modes between
ASOs and Td on gene-inhibition efficiency in bacteria.