Figure 8. Bacterial growth inhibitory effect of LP-Td-L by
inhibiting the acpP gene in E. coli. a) Colony counting
of E. coli after treatment with different concentrations of
Td-Lanti-acpP (0.1, 0.5, or 1 μM) with or without
LP2000 for different times (1, 3 or 5 h). b) Quantitative real-time PCR
analysis of acpP mRNA levels after exposure to different
concentrations of Td-Lanti-acpP or
LP-Td-Lanti-acpP (0.1, 0.5, or 1 μM) for 3 h.
Td-Lmis was used as a negative control to confirm
specific gene inhibiting of ASOs. “*”: p <0.05; “**”:p <0.01; “***”: p <0.001 versus control group.
Supporting Information
Loop-armed DNA Tetrahedron Nanoparticles for Delivering Antisense Oligos
into Bacteria
Yue Hu†, 1, Zhou Chen†, 1, Xinggang
Mao‡, 1, Mingkai Li†, Zheng
Hou†, Jingru Meng†, Xiaoxing
Luo†,*, Xiaoyan Xue†,*