Patients:
This study was performed on a PLS patient and his parents. They
exhibited some of common symptoms of PLS such as palmar-plantar
hyperkeratosis, periodontitis, etc. The declared consent form was
obtained from all members of the family. The study was approved by the
Ethics Committee of Mashhad University of Medical Sciences (# 910523).
The clinicopathological data of patient is summarized in Table 1.