3. Results
The overall AAFEs was 1.25 (ranged: 1.08–1.59) (Eron et al., 2004; Hsu
et al., 1997; Mzayek et al., 2007; Na-Bangchang et al., 1994). The AAFEs
for ritonavir, lopinavir (LPV/r), and chloroquine were 1.30 (Hsu et al.,
1997), 1.17 (Eron et al., 2004) and 1.27 (Mzayek et al., 2007;
Na-Bangchang et al., 1994), respectively. All AAFEs values were within
the accepted ranges (Table S2). Sensitivity coefficients for
Ka, fu, Rbp,
fm, CYP3A4, and fm, CYP2D6 were +0.13,
-0.90, +0.06, -0.50, and +1.34, respectively. All sensitivity
coefficients except for fm,CYP2D6 were less than one,
indicating no significant effects of the model parameters on the AUC
values. Although fm,CYP2D6 was greater than one, this
value was assumed based on the intrinsic clearance of chloroquine from
the vitro studies.7 All parameters were within
the accepted ranges, indicating model reliability.