2.3 Sensitivity analysis
The sensitivity analysis (sensitivity coefficient) was performed to determine the effect of model parameters on the area under the curve (AUC) following the standard regimen of chloroquine (once-daily dose of 250 mg for 14 days). The model parameters for sensitivity analysis were absorption rate (Ka), fraction of unbound drug (fu), liver weight, blood-to-plasma ratio (Rbp), fm, CYP3A4, and fm, CYP2D6. The mathematical equation is as follow:
Sensitivity coefficient = %Y/%X
Where %Y, and %X is the percent change of the AUC336–360 h, and the percent change of model parameter, respectively.