2.6 Simulations of the plasma concentration-time profile of chloroquine when co-administered with lopinavir (LPV/r)
Simulation based on standard drug-drug interactions (DDIs) study approach: multiple doses of the twice-daily regimen of LPV/r (400/100 mg) for 15 consecutive days with the co-administration of a single dose of 250 mg chloroquine on day 15 were simulated.
Simulation based on actual clinical use approach: multiple doses of the twice-daily regimen of LPV/r (400/100 mg) with the co-administration of the once-daily regimen of 250 mg chloroquine given for 14 days were simulated.
AUC ratios (the comparison of chloroquine AUC administration alone, and the chloroquine AUC co-administered with LPV/r) were calculated to determine the effect of LPV/r on chloroquine pharmacokinetics. Dosage regimens of LPV/r for simulation (total=14 consecutive days) were: (i) a twice-daily regimen of 400/100 mg, and (ii) a once-daily regimen of 800/100 mg.