4. Discussion and conclusion
Results of the current study suggest that PBPK modelling successfully
predicted plasma concentration-time profiles of chloroquine and
lopinavir (LPV/r) when given alone, or in combination. The results
suggest that there is a weak but potentially significant DDIs between
chloroquine, and LPV/r. Using PBPK modelling can guide the selection of
appropriate dose regimens in terms of both efficacy, and safety.
Simulations of several dosage regimens of chloroquine administration
alone, and when co-administered with lopinavir (LPV/r) offer potential
dose optimization strategies for the treatment regimen for COVID-19
infected patients.