3.1 Simulations of plasma concentration-time profiles of
chloroquine and lopinavir (LPV/r) when administered alone
Chloroquine: The average unbound Ctrough at 24 hours
following the standard once-daily regimen of 250 mg was 0.06±0.01 mg
l-1. This dose regimen could not provide drug
concentrations over the EC50 level. Time to reach
EC50 was 7 days. Subsequent simulation using the
once-daily dose of 500 mg resulted in the average values of unbound
Ctrough at 24 hours, and the time to reach
EC50 of 0.13±0.02 mg l-1, and 7 days,
respectively.
Lopinavir (LPV/r): The average unbound Ctrough at 24
hours following the standard twice-daily regimen of LPV/r (400/100 mg)
was 0.0341±0.008 mg l-1 (figure 1). Subsequent
simulation using the once-daily dose regimen of 800/100 mg resulted in
the average unbound Ctrough at 24 hours of 0.0468±0.0163
mg l-1 (figure 1).