2.4 Single drug simulation
One hundred virtual population (100 males, aged 30 to 60 years in the fasting state) were simulated. The period of simulation time was based on the maximal admission time of patients in the hospital (14 days) (Chen et al., 2020).The standard dose regimens of chloroquine for rheumatoid arthritis treatment (once-daily dose of 250 mg) were simulated (da Mota et al., 2013).19 In addition, the twice-daily regimen of 400/100 mg LPV/r (based on the regimen used for COVID-19 treatment) were simulated (Chen et al., 2020).