2.5 Estimation of chloroquine toxicity based on the maximum dosage used in clinical trials
The dose of 20 mg/kg body weight/day (total dose of 1,200 mg/day for an average 60 kg body weight) of a once-daily regimen of chloroquine for 6 consecutive weeks (Furst et al., 1999) used for simulations was based on clinically published data. Maximum plasma concentration (Cmax) of unbound chloroquine was used as the pharmacokinetic parameter for chloroquine toxicity.