2.3 Sensitivity analysis
The sensitivity analysis (sensitivity coefficient) was performed to
determine the effect of model parameters on the area under the curve
(AUC) following the standard regimen of chloroquine (once-daily dose of
250 mg for 14 days). The model parameters for sensitivity analysis were
absorption rate (Ka), fraction of unbound drug
(fu), liver weight, blood-to-plasma ratio
(Rbp), fm, CYP3A4, and
fm, CYP2D6. The mathematical equation is as follow:
Sensitivity coefficient = %Y/%X
Where %Y, and %X is the percent change of the
AUC336–360 h, and the percent change of model
parameter, respectively.