2.5 Estimation of chloroquine toxicity based on the maximum
dosage used in clinical trials
The dose of 20 mg/kg body weight/day (total dose of 1,200 mg/day for an
average 60 kg body weight) of a once-daily regimen of chloroquine for 6
consecutive weeks (Furst et al., 1999) used for simulations was based on
clinically published data. Maximum plasma concentration
(Cmax) of unbound chloroquine was used as the
pharmacokinetic parameter for chloroquine toxicity.