2.4 Single drug simulation
One hundred virtual population (100 males, aged 30 to 60 years in the
fasting state) were simulated. The period of simulation time was based
on the maximal admission time of patients in the hospital (14 days)
(Chen et al., 2020).The standard dose regimens of chloroquine for
rheumatoid arthritis treatment (once-daily dose of 250 mg) were
simulated (da Mota et al., 2013).19 In addition, the
twice-daily regimen of 400/100 mg LPV/r (based on the regimen used for
COVID-19 treatment) were simulated (Chen et al., 2020).