Figure legends
Figure 1 Mouse exposure (predicted savolitinib plasma
concentration) versus pMET inhibition for the complete set of CDX and
PDX models used for this analysis. Line fit using an
Emax model (shade area is 95% CI). Across these
studies, a mixture of tumour samples was analysed for pMET by MSD and
WB.
Figure 2 Plots comparing model simulations of pMET inhibition
time-course with observed data following a single administration of
savolitinib at various doses. A : MKN-45; B : EBC-1