B
Figure 3 Tumour growth inhibition with savolitinib. Aand B : EBC-1 cell line models; C : MKN-45 cell line
models.
Figure 4 Predicted relationship between pMET inhibition with
savolitinib and anti-tumour activity as ratio of kill/growth. A value of
1 for anti-tumour activity equates to tumour stasis (no net growth),
whilst values greater than 1 equate to tumour regressions. The modelled
relationships are plotted per CDX/PDX or group of models. A:Time spent with pMET inhibition >90% and anti-tumour
activity; B: Percentage change from baseline in pMET inhibition
and anti-tumour activity; the table provides parameter estimates for
slope and γ.