Figure legends
Figure 1 Mouse exposure (predicted savolitinib plasma concentration) versus pMET inhibition for the complete set of CDX and PDX models used for this analysis. Line fit using an Emax model (shade area is 95% CI). Across these studies, a mixture of tumour samples was analysed for pMET by MSD and WB.
Figure 2 Plots comparing model simulations of pMET inhibition time-course with observed data following a single administration of savolitinib at various doses. A : MKN-45; B : EBC-1