Parameter |
Unit |
Description |
Estimate |
95% CI |
Vmax
|
mg/h/kg |
Maximum elimination rate |
2.41 |
2.36–3.61 |
Vc
|
L/kg |
Central volume |
0.39 |
0.277–0.446 |
ka
|
/h |
Absorption rate constant |
5.07 |
3.17–5.98 |
Vp
|
L/kg |
Peripheral volume |
0.89 |
0.602–0.934 |
Q |
L/h/kg |
Inter-compartment clearance |
0.65 |
0.465–0.765 |
F |
% |
Bioavailability |
28.0 |
25.9–35.0 |
KM |
µg/kg |
Amount of half Vmax
|
616 |
478–972 |
Proportional error |
% |
Proportional residual error |
45 |
39–50 |
Additive error |
ng/ml |
Additive residual error |
4.7 |
1.4–2.8 |
IIV(Vmax) |
% |
Inter-individual variability
Vmax
|
28.2 |
24.4–32.2 |