Figure 4. OGT2115 reduced apoptosis of islet beta cells in STZ mice . (A) Insulin immunohistochemical staining, insulin (INS)/glucagon (GCG) ratios, and TUNEL/insulin double-immunofluorescence staining in islets administered with different doses of OGT2115. Nuclei were stained with DAPI. Scale bar=50 μm. (B) Intensity of insulin immunohistochemical staining based on islet area. (C) Ratio of insulin positive (INS+) cells over glucagon positive (GCG+) cells in the islets of the different treatment groups. (D) Percentage of TUNEL/insulin positive cells over insulin positive cells in the islets of the different treatment groups. *p<0.05, **p<0.01, ***p<0.001, ns=not significant as indicated, n=10.