Classification Evidence of pathogenicity or benign impact
Pathogenic 1 Very Strong + 1 to 4 Strong
1 Very Strong + 2 to 4 Moderate
1 Very Strong + 1 Moderate + 1 Supporting
1 Very Strong + 2 or 3 Supporting
2 to 4 Strong
1 Strong + 3 or 4 Moderate
1 Strong + 2 Moderate + 2 or 3 Supporting
Likely pathogenic 1 Very Strong + 1 Moderate
1 Strong + 1 or 2 Moderate
1 Strong + 2 or 3 Supporting
3 or 4 Moderate
2 Moderate + 2 or 3 Supporting
Benign 1 Stand-alone
2 or 3 Strong
Likely benign 1 Strong + 1 Supporting
3 to 5 Supporting
VUS Other criteria shown above are not met
Contradictory criteria for pathogenic and benign