Conclusions
This study demonstrates that when a surrogate mother carries the embryo of a couple affected by recurrent pregnancy loss due to refractory CHI, pregnancy outcomes are normalised. Although surrogacy is not universally available or acceptable, it should therefore be considered an alternative route to parenthood for these women.
Changing the maternal “host” appears to be highly effective in preventing recurrent CHI. This observation reinforces the hypothesis that CHI is driven by an abnormal maternal immune response against the placenta.
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