3.9 Effect of PA on pancreas histopathology
Figure 3 showed the histopathology of normal and treated group rats. The normal control and normal control received PA (200 mg/kg) demonstrated the normal articulature of pancreas histopathology. STZ induced DM rats pancreas histopathology showed the destruction of pancreatic β-cells. PA -treated rats showed the enlargement of the pancreatic β-cells at dose-dependent manner. An almost similar effect was observed in the glibenclamide treated group rats.
Conclusion
The extraction condition of plant material have been a significant effect on the antioxidant and hypoglycemic effect of Prunus amygdalus extract, but the behavior varied from one response variable to another. The result obtained from the experimental study showed the antihyperglycemic effect and in-vitro inhibition of DPPIV explained the effectiveness of PA in regulating diabetes. The docking study showed the potent DPPIV activity of PA extract (rutin) as compared to marketed drug vildagliptin. Several previous studies showed that the standard drug such as glibenclamide has several effects such as a headache, nausea, low blood sugar level when taken in higher amount etc. Base on the result we can be concluded that the PA extract might be useful in the treatment and prevention of diabetes and its complication such as insulin resistance and spoiled glucose tolerance with DPP-IV inhibitory effect.