3.9 Effect of PA on pancreas histopathology
Figure 3 showed the histopathology of normal and treated group rats. The
normal control and normal control received PA (200 mg/kg)
demonstrated the normal articulature of pancreas histopathology. STZ
induced DM rats pancreas histopathology showed the destruction of
pancreatic β-cells. PA -treated rats showed the enlargement of the
pancreatic β-cells at dose-dependent manner. An almost similar effect
was observed in the glibenclamide treated group rats.
Conclusion
The extraction condition of plant material have been a significant
effect on the antioxidant and hypoglycemic effect of Prunus
amygdalus extract, but the behavior varied from one response variable
to another. The result obtained from the experimental study showed the
antihyperglycemic effect and in-vitro inhibition of DPPIV explained the
effectiveness of PA in regulating diabetes. The docking study
showed the potent DPPIV activity of PA extract (rutin) as
compared to marketed drug vildagliptin. Several previous studies showed
that the standard drug such as glibenclamide has several effects such as
a headache, nausea, low blood sugar level when taken in higher amount
etc. Base on the result we can be concluded that the PA extract
might be useful in the treatment and prevention of diabetes and its
complication such as insulin resistance and spoiled glucose tolerance
with DPP-IV inhibitory effect.