Fig. 1: Microbiomes serve as the foundation for one health: The health of plants, humans, and the environment are interconnected and rely on close association with microbial communities. The beneficial microbial microbes in the plant rhizosphere determine plant productivity by assisting in seed germination, foraging for nutrients under nutrient-limiting conditions, or nutrient recycling along with providing abiotic and biotic stress tolerance through production metabolites and modulating host immunity respectively. In humans, the beneficial microbes introduced via direct consumption of plant products or indirect exposure through the environment contribute to overall health maintenance by boosting the immune system against pathogens, reducing the usage of antimicrobial compounds, and providing some essential nutrients. The beneficial microbes can offer a sustainable solution for the conservation of nature by replacing chemical fertilizers and pesticides responsible for global warming and environmental pollution.